Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site

Ladner, Jane E.; Obmolova, Galina; Teplyakov, Alexey; Howard, Andrew J.; Khil, Pavel P.; Camerini-Otero, R. Daniel; Gilliland, Gary L.
January 2003
BMC Structural Biology;2003, Vol. 3, p1
Academic Journal
Background: The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function. Results: The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid. Conclusion: The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.


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