TITLE

Uteroactive constituents from Combretum kraussii

AUTHOR(S)
Brookes, K. Bridget; Doudoukina, Olga V.; Katsoulis, Lynn C.; Veale, D. Joy H.
PUB. DATE
December 1999
SOURCE
South African Journal of Chemistry;Dec99, Vol. 52 Issue 4, p127
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have established that certain extracts of Combretum kraussii Hochst roots cause contractions in isolated rat uterine tissue, and have purified the most active uterotonic components. The mode of action of the various extracts/components on isolated rat uterus falls into three different categories. The activity of crude extracts from leaves and branches of C .erythrophyllum (Burch.) Sond. and C. kraussii Hochst was also measured. We have identified the following compounds from root extracts: combretastatin, combretastatin A-1 and combretastatin B-1 as well as the corresponding 2-O-Beta-D-glucosides of the latter two combretastatins, Beta-sitosterol, ellagic acid and the di- and trimethyl ethers of ellagic acid. This is the first report of the occurrence of combretastatin and ellagic acid derivatives in this Combretum species.
ACCESSION #
2910831

Tags: COMBRETACEAE;  ROOTS (Botany)

 

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