TITLE

High-resolution comparative mapping among man, cattle and mouse suggests a role for repeat sequences in mammalian genome evolution

AUTHOR(S)
Schibler, Laurent; Roig, Anne; Mahe, Marie-Francoise; Laurent, Pascal; Hayes, Helene; Rodolphe, Francois; Cribiu, Edmond P
PUB. DATE
January 2006
SOURCE
BMC Genomics;2006, Vol. 7, p194
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Comparative mapping provides new insights into the evolutionary history of genomes. In particular, recent studies in mammals have suggested a role for segmental duplication in genome evolution. In some species such as Drosophila or maize, transposable elements (TEs) have been shown to be involved in chromosomal rearrangements. In this work, we have explored the presence of interspersed repeats in regions of chromosomal rearrangements, using an updated high-resolution integrated comparative map among cattle, man and mouse. Results: The bovine, human and mouse comparative autosomal map has been constructed using data from bovine genetic and physical maps and from FISH-mapping studies. We confirm most previous results but also reveal some discrepancies. A total of 211 conserved segments have been identified between cattle and man, of which 33 are new segments and 72 correspond to extended, previously known segments. The resulting map covers 91% and 90% of the human and bovine genomes, respectively. Analysis of breakpoint regions revealed a high density of species-specific interspersed repeats in the human and mouse genomes. Conclusion: Analysis of the breakpoint regions has revealed specific repeat density patterns, suggesting that TEs may have played a significant role in chromosome evolution and genome plasticity. However, we cannot rule out that repeats and breakpoints accumulate independently in the few same regions where modifications are better tolerated. Likewise, we cannot ascertain whether increased TE density is the cause or the consequence of chromosome rearrangements. Nevertheless, the identification of high density repeat clusters combined with a well-documented repeat phylogeny should highlight probable breakpoints, and permit their precise dating. Combining new statistical models taking the present information into account should help reconstruct ancestral karyotypes.
ACCESSION #
28858684

 

Related Articles

  • Map Position and Expression of the Genes in the 38 Region of Drosophila. Butler, Heather; Levine, Sylvia; Xingda Wang; Bonyadi, Sheida; Fu, Germaine; Lasko, Paul; Suter, Beat; Doerig, Ruth // Genetics;Aug2001, Vol. 158 Issue 4, p1597 

    Presents a genetic map of cytological region 38 of Drosophila. Extraction of biological information with the completion of the Drosophila genome sequence; Definitions of additional functions by trans-heterozygous combinations of deficiencies; Analysis of the developmental expression pattern...

  • Emerging technologies for gene manipulation in Drosophila melanogaster. Venken, Koen J. T.; Bellen, Hugo J. // Nature Reviews Genetics;Mar2005, Vol. 6 Issue 3, p167 

    The popularity of Drosophila melanogaster as a model for understanding eukaryotic biology over the past 100 years has been accompanied by the development of numerous tools for manipulating the fruitfly genome. Here we review some recent technologies that will allow Drosophila melanogaster to be...

  • A Genetic Linkage Map for the Tiger Pufferfish, Takifugu rubripes. Kai, Wataru; Kikuchi, Kiyoshi; Fujita, Masashi; Suetake, Hiroaki; Fujiwara, Atushi; Yoshiura, Yasutoshi; Ototake, Mitsuru; Venkatesh, Byrappa; Miyaki, Kadoo; Suzuki, Yuzuru // Genetics;Sep2005, Vol. 171 Issue 1, p227 

    The compact genome of the tiger pufferfish, Takifugu rubripes (fugu), has been sequenced to the "draft" level and annotated to identify all the genes. However, the assembly of the draft genome sequence is highly fragmented due to the lack of a genetic or a physical map. To determine the...

  • An Ancient RNase HI Splice Junction Mutant Preserved in a 19-Million-Year-Old Genetic Fossil in Ape Genomes. Devor, E. J.; Moffat-Wilson, K. // Journal of Heredity;May/Jun2004, Vol. 95 Issue 3, p257 

    A retroprocessed pseudogene (retropseudogene) descended from the gene encoding ribonuclease (RNase) HI has been found in ape genomes that preserves a splice junction mutation event that altered the carboxyl-terminal end of the enzyme. The GT → GC transition mutant at the 5' splice...

  • Equine genome mapped.  // Irish Veterinary Journal;Apr2007, Vol. 60 Issue 4, p213 

    The article reports on the implementation of equine genome mapping in Ireland. It is stated that the first draft of the genome sequence has been made public on February 2007, which represents over ten years and $15 million of work. Information concerning the implementation of the Horse Genome...

  • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Hillier, LaDeana W.; Miller, Webb; Birney, Ewan; Warren, Wesley; Hardison, Ross C.; Ponting, Chris P.; Bork, Peer; Burt, David W.; Groenen, Martien A. M.; Delany, Mary E.; Dodgson, Jerry B.; Chinwalla, Asif T.; Cliften, Paul F.; Clifton, Sandra W.; Delehaunty, Kimberly D.; Fronick, Catrina; Fulton, Robert S.; Graves, Tina A.; Kremitzki, Colin; Layman, Dan // Nature;12/9/2004, Vol. 432 Issue 7018, p695 

    We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome-composed of approximately one billion base pairs of...

  • Genome-enabled hitchhiking mapping identifies QTLs for stress resistance in natural Drosophila. Nuzhdin, S. V.; Harshman, L. G.; Zhou, M.; Harmon, K. // Heredity;Sep2007, Vol. 99 Issue 3, p313 

    Identification of genes underlying complex traits is an important problem. Quantitative trait loci (QTL) are mapped using marker-trait co-segregation in large panels of recombinant genotypes. Most frequently, recombinant inbred lines derived from two isogenic parents are used. Segregation...

  • High-Resolution Mapping of the Drosophila Fourth Chromosome Using Site-Directed Terminal Deficiencies. Sousa-Neves, Rui; Lukacsovich, Tamas; Mizutani, Claudia Mieko; Locke, John; Podemski, Lynn; Marsh, J. Lawrence // Genetics;May2005, Vol. 170 Issue 1, p127 

    For more than 80 years, the euchromatic right arm of the Drosophila fourth chromosome (101F–102F) has been one of the least genetically accessible regions of the fly genome despite the fact that many important genes reside there. To improve the mapping of genes on the fourth chromosome,...

  • Annotation of the Drosophila genome. Karlin, Samuel; Bergman, Aviv; Gentles, Andrew J. // Nature;5/17/2001, Vol. 411 Issue 6835, p259 

    Examines the genome sequence of the fruitfly Drosophila. Comparison of the Drosophila protein sequences created before 1999 from the SwissProt database to the Celera proteome; Use of the gene-discovery algorithms to exploit differences between exons and introns.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics