Selection of patients for liver transplantation and allocation of donated livers in the UK

Neuberger, J.; Gimson, A.; Davies, M.; Akyol, M.; O'Grady, J.; Burroughs, A.; Hudson, M.
February 2008
Gut;Feb2008, Vol. 57 Issue 2, p252
Academic Journal
Background: The increasing shortfall between the number of patients who would benefit from liver transplantation and the availability of donor livers means that rationing has to occur. The processes of selection of patients for transplantation and for allocation of donor livers should be done according to ethical and, where possible, evidence-based criteria so that there is clarity and that the competing requirements of equity, justice, utility and benefit can be balanced. Methods: To achieve these goals for patients in the United Kingdom in need of transplantation, we have developed guidelines for the selection of patients to the national waiting list based on the risk of death without a transplant and the ability of the procedure to improve the recipient's quality of life. Guidelines have been developed for both those with acute liver failure and chronic liver disease. Allocation will depend on matching of the donor liver to the recipient. Results: The proposed system, to be introduced into the UK compares with some other systems, where different models for selection and allocation have been introduced.


Related Articles

  • Biliary complications after a right-lobe living donor liver transplantation. Yazumi, Shujiro; Chiba, Tsutomu // Journal of Gastroenterology;Sep2005, Vol. 40 Issue 9, p861 

    Right-lobe living donor liver transplantation (RL-LDLT) has become an acceptable procedure for adult patients with end-stage liver disease in this decade. However, biliary complications in RL-LDLT remain a serious problem: the incidence of anastomotic biliary leakage and stricture after RL-LDLT...

  • Adult-to-Adult Transplantation of the Right Hepatic Lobe from a Living Donor. Trotter, James F.; Wachs, Michael; Everson, Gregory T.; Kam, Igal // New England Journal of Medicine;4/4/2002, Vol. 346 Issue 14, p1074 

    Focuses on adult-to-adult transplantation of the right hepatic lobe from a living donor. History of living-donor liver transplantation; Selection of donors and recipients; Current outcomes; Ongoing controversies surrounding how much risk is acceptable for the donor, relative to the outcome in...

  • Sisters Share Special Bond After Rare Living-Donor Transplant.  // Ascribe Newswire: Medicine;4/21/2004, p52 

    Jessica Eveleth will celebrate her 21st birthday on April 20, but she's already received the gift of a lifetime. Her sister Jamie, 18, donated a segment of her small intestine to Jessica in a rare living-donor transplant at the University of Illinois Medical Center at Chicago on March 23.

  • Transplant to a friend. Comarow, Avery // U.S. News & World Report;7/23/2001, Vol. 131 Issue 3, p46 

    Details the living-donor liver transplant (LDLT) operation at Mount Sinai Medical Center in New York between friends, Vincent Betts and Harvey Davis. Background on Davis and his illness with hepatitis C; Reason that Betts donated part of his liver to be transplanted; Controversy surrounding the...

  • MULTIORGANSKA EKSPLANTACIJA. Vuković, Milivoje; Moljevć, Nebojša; Milošević, Zoran; Katanić, Nenad; Krivokuća, Dragan // Medicinski Pregled / Medical Review;2007, Vol. 60 Issue 7/8, p339 

    Introduction: Liver transplantation is the most demanding of all solid organ transplantation. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for...

  • Brother, can you spare a... Hensrud, Donald D. // Fortune;5/26/2003, Vol. 147 Issue 10, p176 

    Focuses on the transplantation of organs. Possibility to transplant kidneys, hearts, livers, corneas, bone marrow, stem cells, lungs and even intestines; Use of laparoscopic surgery to remove a kidney from a living donor; Usage of immunosuppressive drugs in case of heart and liver...

  • Erweiterte Spenderkriterien der Bundesärztekammer. Schrem, H.; Reichert, B.; Frühauf, N.; Kleine, M.; Zachau, L.; Becker, T.; Lehner, F.; Bektas, H.; Klempnauer, J. // Der Chirurg;Nov2012, Vol. 83 Issue 11, p980 

    Introduction: Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. The ability of the number of fulfilled extended donor criteria as currently defined by the...

  • Circle of Life. Espinoza, Galina; Brailsford, Karen; Dinkelspiel, Frances // People;1/14/2002, Vol. 57 Issue 1, p46 

    Reports on the rare 'domino' liver transplant in Los Angeles, California involving a liver donor that saved the lives of both Jeff Cross and Lily Cheng. Details of the triple surgery; Way that Doug Andrews risked his life by donating part of his healthy liver to Cross; Significance of the...

  • Who is willing to take the risk? Assessing the readiness for living liver donation in the general German population. Popp, F. C.; Eggert, N.; Hoy, L.; Lang, S. A.; Obed, A.; Piso, P.; Schlitt, H. J.; Dahlke, M. H. // Journal of Medical Ethics;Jul2006, Vol. 32 Issue 7, p389 

    Background: Shortage of donor organs is one of the major problems for liver transplant programmes. Living liver donation is a possible alternative, which could increase the amount of donor organs available in the short term. Objective: To assess the attitude towards living organ donation in the...


Read the Article


Sign out of this library

Other Topics