TITLE

Ranibizumab Combined With Low-Dose Sorafenib for Exudative Age-Related Macular Degeneration

AUTHOR(S)
Diago, Teresa; Pulido, Jose S.; Molina, Julian R.; Collet, Lucienne C.; Link, Thomas P.; Ryan, Jr., Edwin H.
PUB. DATE
February 2008
SOURCE
Mayo Clinic Proceedings;Feb2008, Vol. 83 Issue 2, p231
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Angiogenesis Is a common factor in the pathogenesis of cancer and In exudative age-related macular degeneration (AMD). Therefore, angiogenesis inhibition has been developed as a therapeutic strategy. We report 2 cases of recurrent exudative AMD in which oral sorafenib, a tyrosine kinase Inhibitor approved for cancer, was added to intravitreal ranibizumab, an antibody to vascular endothelial growth factor. These 2 patients were followed up by determination of visual acuity, fluorescein angiography, fundoscopy, and optical coherence tomography. The visual acuity of I patient Improved from 20/70 to 20/60 while he was receiving sorafenib therapy; that of the other did not. Marked improvement was noted in both patients on optical coherence tomography. Additionally, both patients appeared to receive some benefit when low-dose oral sorafenib was used as monotherapy after Its initial addition to ranibizumab therapy. Randomized trials of adding sorafenib to standard therapy for patients with neo-vascular AMD should be considered.
ACCESSION #
28841085

 

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