Helicobacter pylori Vaccine: From Past to Future

Agarwal, Kanishtha; Agarwal, Shvetank
February 2008
Mayo Clinic Proceedings;Feb2008, Vol. 83 Issue 2, p169
Academic Journal
Helicobacter pylon infection is highly prevalent worldwide and is an important cause of gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue lymphoma (MALToma), and gastric adenocarcinoma. Infection is usually acquired during child- hood and tends to persist unless treated. Because eradication requires treatment with multidrug regimens, prevention of initial infection by a suitable vaccine is attractive. Although immunization with H pylori protein subunits has been encouraging in animals, similar vaccine trials in humans have shown adjuvant-related adverse effects and only moderate effectiveness. Newer immunization approaches (use of DNA, live vectors, bacterial ghosts, and microspheres) are being developed. Several questions about when and whom to vaccinate will need to be appropriately answered, and a cost-effective vaccine production and delivery strategy will have to be useful for developing countries. For this review, we searched MEDLINE using the Medical Subject Heading (MeSH) terms Helicobacter pylon and vaccines for articles in English from 1990 to 2007.


Related Articles

  • Literature reviews: General pediatrics. J.B.L. // Clinical Pediatrics;Jun1998, Vol. 37 Issue 6, p392 

    Discusses the article `Randomized Placebo-Controlled Trial of Rhesus-Human Reassortant Rotavirus Vaccine for Prevention of Severe Rotavirus Gastroenteritis,' by J. Josensuu, E. Koshenniemi et al.

  • Good news on gastro.  // Australia's Parents;Apr/May98, Issue 104, p36 

    Presents information pertaining gastrointeritis in children, with reference to the Rotavirus which is responsible for gastroenteritis. Indication that a vaccine may become available for the treatment of gastroenteritis; How the vaccine will be administered; Length of time the vaccine will...

  • Helicobacter heilmannii Gastritis. Xia Chen; Hoda, Syed A.; Petrovic, Lydia // International Journal of Surgical Pathology;Oct2003, Vol. 11 Issue 4, p315 

    Discusses the pathogenes of chronic active gastritis. Identification of bacilli with corkscrew; Specifications of Helicobacter heilmannii; Specification of immonustain for Helicobacter pylori crossreacted with this bacterium.

  • Cytolethal Distending Toxin in Avian and Human Isolates of Helicobacter pullorum. Young, Vincent B.; Chih-Ching Chien; Knox, Kimberly A.; Taylor, Nancy S.; Schauer, David B.; Fox, James G. // Journal of Infectious Diseases;8/1/2000, Vol. 182 Issue 2 

    Examines the toxins isolated from the Helicobacter pullorum. Identification of the DNA sequence and cytotoxic activity of the organism; Presence of the virulence factor of the organism; Causes of human gastroenteritis.

  • Antex awarded grant to continue development of pylori vaccine.  // PharmaWatch: Biotechnology;August 2004, Vol. 3 Issue 8, p7 

    Antex Biologics Inc. has received a $2 million grant from the National Institute of Allergy and Infectious Disease to allow it to further its investigations into its Helicobacter pylori vaccine candidate. The $2 million grant is distributed over three years and supports the development of a dry...

  • Many questions remain about immunotherapies for cancer. Gebhart, Fred // Drug Topics;5/6/2002, Vol. 146 Issue 9, p36 

    Focuses on studies regarding anticancer vaccines in the U.S. Information on trial studies concerning anticancer vaccines for leukemia; Details on the potential use of cellular antigens for cancer immunotherapy; Properties of successful immunotherapeutics.

  • Days of Molecular Medicine '03.  // Nature Medicine;Apr2003, Vol. 9 Issue 4, p365 

    Reports on a convention on immunotherapy held in California as of April 1, 2003. Goal of immunotherapy; Obstacles in immunotherapy; Efforts of the government to the development of immunotherapy and vaccines for viral diseases.

  • Advances in Development of Countermeasures for Potential Biothreat Agents. Pittman, Phillip R.; McKee Jr., Kelly T.; Dembek, Zygmunt F. // Advances in Preventive Medicine;2012, p1 

    An introduction is presented in which the editor discusses various reports within the issue on topics including passive and active surveillance, regulatory framework for licensing medical countermeasures against biological threats in the U.S., and vaccines and immunotherapies for plague.

  • Conceptual Spaces of the Immune System. Fierz, Walter; Walsh, Craig Michael; Sridhar, Saranya; McKinstry, Karl Kai // Frontiers in Immunology;12/13/2016, Vol. 7, p1 

    The immune system can be looked at as a cognitive system. This is often done in analogy to the neuro-psychological system. Here, it is demonstrated that the cognitive functions of the immune system can be properly described within a new theory of cognitive science. Gärdenfors' geometrical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics