TITLE

Association Between the Paraoxonase-1 192Q>R Allelic Variant and Coronary Endothelial Dysfunction in Patients With Early Coronary Artery Disease

AUTHOR(S)
Lavi, Shahar; McConnell, Joseph P.; Lavi, Ronit; Barsness, Gregory W.; Rihal, Charanjit S.; Novak, Gregory D.; Lerman, Lilach O.; Lerman, Amir
PUB. DATE
February 2008
SOURCE
Mayo Clinic Proceedings;Feb2008, Vol. 83 Issue 2, p158
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothellal dysfunction, an early stage of atherosclerosis. PATIENTS AND METHODS: We assessed 192Q>R and 55L>M allelic variants of the paraoxonase gene and coronary endothellal function in response to Intracoronary acetyicholine In 99 patients (52 with homozygous QQ, 47 with homozygous RR or heterozygous QR). The study was conducted from September 1, 2002, through November 30, 2004. RESULTS: Of 52 homozygous QQ patients, 39 (75%) had endothehal dysfunction vs 20 (43%) of the 47 RR/QR patients (P=.001), and this association remained significant after adjustment In a multivariable linear regression model (P=.005). In homozygous QQ vs RR/QR patients, epicardial arterial diameter decreased more (percent change In diameter, -22%±21% vs -9%±16%, respectively, P=.002), coronary blood flow Increased less (+37%±77% vs +75%±75%, P=.02) In response to acetylchollne, and oxidized LDL levels were higher. The 55L>M allelic variant was not significantly associated with endothelial dysfunction and had no effect on the association between endothelial dysfunction and the 192Q>R allelic variant. CONCLUSION: The 192Q>R allelic variant of the paraoxonase-1 gene is associated with coronary endothellal dysfunction. The current study provides further information regarding the potential mechanisms by which this allelic variant contributes to early atherosclerosis In humans.
ACCESSION #
28841074

 

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