Association Between the Paraoxonase-1 192Q>R Allelic Variant and Coronary Endothelial Dysfunction in Patients With Early Coronary Artery Disease

Lavi, Shahar; McConnell, Joseph P.; Lavi, Ronit; Barsness, Gregory W.; Rihal, Charanjit S.; Novak, Gregory D.; Lerman, Lilach O.; Lerman, Amir
February 2008
Mayo Clinic Proceedings;Feb2008, Vol. 83 Issue 2, p158
Academic Journal
OBJECTIVE: To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothellal dysfunction, an early stage of atherosclerosis. PATIENTS AND METHODS: We assessed 192Q>R and 55L>M allelic variants of the paraoxonase gene and coronary endothellal function in response to Intracoronary acetyicholine In 99 patients (52 with homozygous QQ, 47 with homozygous RR or heterozygous QR). The study was conducted from September 1, 2002, through November 30, 2004. RESULTS: Of 52 homozygous QQ patients, 39 (75%) had endothehal dysfunction vs 20 (43%) of the 47 RR/QR patients (P=.001), and this association remained significant after adjustment In a multivariable linear regression model (P=.005). In homozygous QQ vs RR/QR patients, epicardial arterial diameter decreased more (percent change In diameter, -22%±21% vs -9%±16%, respectively, P=.002), coronary blood flow Increased less (+37%±77% vs +75%±75%, P=.02) In response to acetylchollne, and oxidized LDL levels were higher. The 55L>M allelic variant was not significantly associated with endothelial dysfunction and had no effect on the association between endothelial dysfunction and the 192Q>R allelic variant. CONCLUSION: The 192Q>R allelic variant of the paraoxonase-1 gene is associated with coronary endothellal dysfunction. The current study provides further information regarding the potential mechanisms by which this allelic variant contributes to early atherosclerosis In humans.


Related Articles

  • Relationship Between Mean Platelet Volume and Coronary Blood Flow in Patients with Atrial Fibrillation Feng, Chong; Mei, Weiyi; Luo, Chufan; Long, Ming; Hu, Xun; Huang, Yong; Hao, Yuantao; Du, Zhimin // Heart, Lung & Circulation;Jan2013, Vol. 22 Issue 1, p43 

    Introduction: Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and...

  • Determinants of coronary collateral circulation in patients with coronary artery disease. Zorkun, Cafer; Akkaya, Emre; Zorlu, Ali; Tandoğan, İzzet // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Mar2013, Vol. 13 Issue 2, p146 

    Objective: This study aims to identify possible determinants of coronary collaterals in patients with severe coronary artery disease. Methods: The current study has a retrospective cohort design. Seventy four patients with ≥90% stenosis or total occlusion of the left anterior descending...

  • Treatment response after repeated administration of C1 esterase inhibitor for successive acute hereditary angioedema attacks. Craig, Timothy J.; Bewtra, Againdra K.; Hurewitz, David; Levy, Robyn; Janss, Gerti; Jacobson, Kraig W.; Packer, Flint; Bernstein, Jonathan A.; Rojavin, Mikhail A.; Machnig, Thomas; Keinecke, Heinz-Otto; Wasserman, Richard L. // Allergy & Asthma Proceedings;Jul2012, Vol. 33 Issue 4, p354 

    Placebo-controlled studies established the efficacy of replacement therapy with C1 esterase inhibitor (C1-INH) concentrate for treating single acute hereditary angioedema (HAE) attacks, but only limited data from prospective studies are available on repeated treatment of successive HAE attacks....

  • Effect of family history of type-2 diabetes on coronary flow reserve and it's relationship with insulin resistance: an observational study. Çalışkan, Mustafa; Pamuk, Barış Önder; Güllü, Hakan; Çiftçi, Özgür; Çaliskan, Zuhal; Erdogan, Dogan; Güven, Aytekin; Polat, Ezgi; Müderrisoglu, Haldun // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Feb2013, Vol. 13 Issue 1, p48 

    Objective: Coronary microvascular function among offspring of patients with diabetes mellitus might be compromised when compared to persons with no first-degree relative with diabetes mellitus. The aim of the study was to evaluate effect of family history of type-2 diabetes on coronary flow...

  • Evaluation of Tp-Te Interval and Tp-Te/QT Ratio in Patients with Coronary Slow Flow Tp-Te/QT Ratio and Coronary Slow Flow. Tenekecioglu, Erhan; Karaagac, Kemal; Yontar, Osman Can; Agca, Fahriye Vatansever; Ozluk, Ozlem Arican; Tutuncu, Ahmet; Arslan, Burhan; Yilmaz, Mustafa // Eurasian Journal of Medicine;Jun2015, Vol. 47 Issue 2, p104 

    Objective: Coronary slow flow (CSF) phenomenon is described by angiographically normal coronary arteries with delayed opacification of the distal vasculature. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-Te) may correspond to...

  • Age estimation based on a combined arteriosclerotic index. Horny, Lukas; Adamek, Tomas; Chlup, Hynek; Zitny, Rudolf // International Journal of Legal Medicine;Mar2012, Vol. 126 Issue 2, p321 

    This study introduces a new quantity, the combined arteriosclerotic index (CAI), which is defined as the ratio between the diameter and the longitudinal prestrain of an artery. The longitudinal prestrain has been adopted as the ratio between the in situ length and the excised length of the...

  • B-mode ultrasound common carotid artery intima-media thickness and external diameter: cross-sectional and longitudinal associations with carotid atherosclerosis in a large population sample. Eigenbrodt, Marsha L.; Bursac, Zoran; Tracy, Richard E.; Mehta, Jawahar L.; Rose, Kathryn M.; Couper, David J. // Cardiovascular Ultrasound;2008, Vol. 6, Special section p1 

    Background: Arterial diameter and intima-media thickness (IMT) enlargement may each be related to the atherosclerotic process. Their separate or combined enlargement may indicate different arterial phenotypes with different atherosclerosis risk. Methods: We investigated cross-sectional (baseline...

  • Lead and CKD. Grootendorst, Diana C.; Elliott, Elise G.; Michels, Wieneke M.; Gansevoort, Ron T.; Halbesma, Nynke // Nephrology Dialysis Transplantation;Aug2013, Vol. 28 Issue 8, pe7 

    No abstract available.

  • Relationship quality and burden among caregivers for late-stage cancer patients. Francis, Linda E.; Worthington, Julie; Kypriotakis, Georgios; Rose, Julia H. // Supportive Care in Cancer;Nov2010, Vol. 18 Issue 11, p1429 

    Objective: This study explores how caregiver relationship quality with family, patient, and patient's health care provider (HCP) is associated with subjective caregiver burden during the early treatment phase for late-stage cancer. Method: Burden and relationship quality were assessed in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics