TITLE

A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale in silico analysis

AUTHOR(S)
Benbow, Lawrence; Wang, Lynn; Laverty, Maureen; Suxing Liu; Ping Qiu; Bond, Richard W.; Gustafson, Eric; Hedrick, Joseph A.; Kostich, Mitchell; Greene, Jonathan R.; Wang, Luquan
PUB. DATE
January 2002
SOURCE
BMC Genomics;2002, Vol. 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8. Results: IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries. Conclusions: This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes.
ACCESSION #
28834641

 

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