TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins

Keresztes, Gabor; Mutai, Hideki; Heller, Stefan
January 2003
BMC Genomics;2003, Vol. 4, p24
Academic Journal
Background: Mutations in the transmembrane cochlear expressed gene 1 (TMC1) cause deafness in human and mouse. Mutations in two homologous genes, EVER1 and EVER2 increase the susceptibility to infection with certain human papillomaviruses resulting in high risk of skin carcinoma. Here we report that TMC1, EVER1 and EVER2 (now TMC6 and TMC8) belong to a larger novel gene family, which is named TMC for trans membrane channel-like gene family. Results: Using a combination of iterative database searches and reverse transcriptase-polymerase chain reaction (RT-PCR) experiments we assembled contigs for cDNA encoding human, murine, puffer fish, and invertebrate TMC proteins. TMC proteins of individual species can be grouped into three subfamilies A, B, and C. Vertebrates have eight TMC genes. The majority of murine TMC transcripts are expressed in most organs; some transcripts, however, in particular the three subfamily A members are rare and more restrictively expressed. Conclusion: The eight vertebrate TMC genes are evolutionary conserved and encode proteins that form three subfamilies. Invertebrate TMC proteins can also be categorized into these three subfamilies. All TMC genes encode transmembrane proteins with intracellular amino- and carboxyltermini and at least eight membrane-spanning domains. We speculate that the TMC proteins constitute a novel group of ion channels, transporters, or modifiers of such.


Related Articles

  • Regional Ion Channel Gene Expression Heterogeneity and Ventricular Fibrillation Dynamics in Human Hearts. Sivagangabalan, Gopal; Nazzari, Hamed; Bignolais, Olivier; Maguy, Ange; Naud, Patrice; Farid, Talha; Massé, Stéphane; Gaborit, Nathalie; Varro, Andras; Nair, Krishnakumar; Backx, Peter; Vigmond, Edward; Nattel, Stanley; Demolombe, Sophie; Nanthakumar, Kumaraswamy // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Rationale: Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role. Objectives: To define regional ion channel expression in myopathic hearts compared to normal hearts, and...

  • Remodelling of human atrial K currents but not ion channel expression by chronic β-blockade. Marshall, Gillian; Russell, Julie; Tellez, James; Jhund, Pardeep; Currie, Susan; Dempster, John; Boyett, Mark; Kane, Kathleen; Rankin, Andrew; Workman, Antony // Pflugers Archiv European Journal of Physiology;Apr2012, Vol. 463 Issue 4, p537 

    Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K currents. The aim of this study was to investigate the effects of...

  • Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers. Köberle, Verena; Pleli, Thomas; Schmithals, Christian; Augusto Alonso, Eduardo; Haupenthal, Jörg; Bönig, Halvard; Peveling-Oberhag, Jan; Biondi, Ricardo M.; Zeuzem, Stefan; Kronenberger, Bernd; Waidmann, Oliver; Piiper, Albrecht // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Background:MicroRNAs circulating in the blood, stabilized by complexation with proteins and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as biomarkers. The consequences of their differential association with lipids/vesicles for their stability and use as...

  • Genetic Mapping and Characteristics of Genes Specifically or Preferentially Expressed during Fiber Development in Cotton. Ximei Li; Daojun Yuan; Jinfa Zhang; Zhongxu Lin; Xianlong Zhang // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Cotton fiber is an ideal model to study cell elongation and cell wall construction in plants. During fiber development, some genes and proteins have been reported to be specifically or preferentially expressed. Mapping of them will reveal the genomic distribution of these genes, and will...

  • Characterization of barley Prp1 gene and its expression during seed development and under abiotic stress. Jiang, Qian-Tao; Liu, Tao; Ma, Jian; Wei, Yu-Ming; Lu, Zhen-Xiang; Lan, Xiu-Jin; Dai, Shou-Fen; Zheng, You-Liang // Genetica;Oct2011, Vol. 139 Issue 10, p1283 

    The pre-mRNA processing ( Prp1) gene encodes a spliceosomal protein. It was firstly identified in fission yeast and plays a regular role during spliceosome activation and cell cycle. Plant Prp1 genes have only been identified from rice, Sorghum and Arabidopsis thaliana. In this study, we...

  • Isolation, nucleotide identification and tissue expression of three novel ovine genes— SLC25A4, SLC25A5 and SLC25A6. Yang, Liangyu; He, Yiduo; Kong, Qingbo; Zhang, Wencai; Xi, Dongmei; Mao, Huaming; Deng, Weidong // Molecular Biology Reports;Jul2010, Vol. 37 Issue 6, p2743 

    The complete coding sequences of three of sheep genes SLC25A4, SLC25A5 and SLC25A6 were firstly amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) according to the conserved sequence information of the cattle or other mammals and known highly homologous sheep ESTs....

  • Evaluating of suppressor of zeste 12 and chromobox homolog 8 genes expression showed two possible origins for gastric cancer development. Ghalandary, M.; Behmanesh, M.; Sadeghizadeh, M. // Indian Journal of Cancer;Jan-Mar2015, Vol. 52 Issue 1, p27 

    Context: Changes in genome, made by multiple genetic and epigenetic alterations result to the cancer initiation and progression. Suppressor of zeste 12 (SUZ12) and chromobox homolog 8 (CBX8) proteins are two components of epigenetic regulators that their function in the initiation...

  • Two Closely Related Subclass II SnRK2 Protein Kinases Cooperatively Regulate Drought-Inducible Gene Expression. Mizoguchi, Masahide; Umezawa, Taishi; Nakashima, Kazuo; Kidokoro, Satoshi; Takasaki, Hironori; Fujita, Yasunari; Yamaguchi-Shinozaki, Kazuko; Shinozaki, Kazuo // Plant & Cell Physiology;May2010, Vol. 51 Issue 5, p842 

    The subclass III group of SNF1-related protein kinase 2 (SnRK2) members is known to play an important role in ABA and osmotic stress signaling in Arabidopsis; however, the roles of other subclasses remain elusive. Here, we established a double mutant of SRK2C/SnR2.8 and SRK2F/SnRK2.7 to...

  • Molecular cloning of heat shock protein 60 ( PtHSP60) from Portunus trituberculatus and its expression response to salinity stress. Xu, Qianghua; Qin, Ye // Cell Stress & Chaperones;Winter2012, Vol. 17 Issue 5, p589 

    Heat shock protein 60 (HSP60) is a highly conserved and multi-functional molecular chaperone that plays an essential role in both cellular metabolism and stress response. Portunus trituberculatus is an important marine fishery and aquaculture species, and water salinity condition influenced its...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics