Teratogenic Effects of Diazepam Intake During Pregnancy Leading to Cleft Lip and Palatal Anomalies

Takzare, Nasrin; Hosseini, Mir-Jamal; Takzare, Alireza; Bakhtiarian, Azam; Yarmohammadi, Kamran
November 2007
Journal of Medical Sciences;2007, Vol. 7 Issue 7, p1177
Academic Journal
In this research, it has studied the teratogenicity of Diazepam intake during pregnancy and its effects on cleft lip and palatal development. About 30 virgin rats of known age and weight were used. After pregnancy, they were divided in three groups: The first groups were control group which were injected daily with distilled water. The second groups that were injected daily Diazepam 3 mg kg-1 day-1 and the third injected daily with Diazepam 8 mg kg-1 day-1. After embryonic period the pregnant rats were scarified and the embryos were divided in to three groups. The embryos were studied macroscopically for anomalies and then the tissue were fixed and processed, stained and examined microscopically. Anomalies of cleft lip and palatal were evaluated. The findings confirmed that the ratio of normal eye in the control group is 100% and in the experimental groups (1 and 2) were 97.6 and 71.3%, respectively. The statistical results indicate that diazepam intake during pregnancy can lead to cleft lip and palatal anomalies.


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