TITLE

Raman spectroscopic investigation of cocaine hydrochloride on human nail in a forensic context

AUTHOR(S)
Ali, Esam M. A.; Edwards, Howell G. M.; Hargreaves, Michael D.; Scowen, Ian J.
PUB. DATE
February 2008
SOURCE
Analytical & Bioanalytical Chemistry;Feb2008, Vol. 390 Issue 4, p1159
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study describes the application of Raman spectroscopy to the detection of drugs of abuse and noncontrolled substances used in the adulteration of drugs of abuse on human nail. Contamination of the nail may result from handling or abusing these substances. Raman spectra of pure cocaine hydrochloride, a seized street sample of cocaine hydrochloride (77%), and paracetamol could be acquired from drug crystals on the surface of the nail. An added difficulty in the analytical procedure is afforded by the presence of a nail varnish coating the nail fragment. By using confocal Raman spectroscopy, spectra of the drugs under nail varnish could be acquired. Spectra of the drugs could be readily obtained nondestructively within three minutes with little or no sample preparation. Raman spectra could be acquired from drug particles with an average size of 5–20 μm. Acquisition of Raman point maps of crystals from both pure and street samples of cocaine hydrochloride under nail varnish is also reported. [Figure not available: see fulltext.]
ACCESSION #
28804056

 

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