Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage

Kleim, Jeffrey A.; Jones, Theresa A.
February 2008
Journal of Speech, Language & Hearing Research;Feb2008, Vol. 51 Issue 1, pS225
Academic Journal
Purpose: This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain. Method: Neuroscience research using a variety of models of learning, neurological disease, and trauma are reviewed from the perspective of basic neuroscientists but in a manner intended to be useful for the development of more effective clinical rehabilitation interventions. Results: Neural plasticity is believed to be the basis for both learning in the intact brain and relearning in the damaged brain that occurs through physical rehabilitation. Neuroscience research has made significant advances in understanding experience-dependent neural plasticity, and these findings are beginning to be integrated with research on the degenerative and regenerative effects of brain damage. The qualities and constraints of experience-dependent neural plasticity are likely to be of major relevance to rehabilitation efforts in humans with brain damage. However, some research topics need much more attention in order to enhance the translation of this area of neuroscience to clinical research and practice. Conclusion: The growing understanding of the nature of brain plasticity raises optimism that this knowledge can be capitalized upon to improve rehabilitation efforts and to optimize functional outcome.


Related Articles

  • Educación y Neurociencia. Santos, Francisco Rodríguez // Psicologia Educativa;jun2009, Vol. 15 Issue 1, p27 

    The aim of this review is to explain some of the implications of neuroscience's data for the educational process. First, learning is considered one more factor of neuronal plasticity. Second, the evidence of the close links between brain and body reveals the interaction between cognitive and...

  • Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury. Alwis, Dasuni S.; Rajan, Ramesh // Frontiers in Systems Neuroscience;Sep2014, Vol. 8, p1 

    The brain's life-long capacity for experience-dependent plasticity allows adaptation to new environments or to changes in the environment, and to changes in internal brain states such as occurs in brain damage. Since the initial discovery by Hebb (1947) that environmental enrichment (EE) was...

  • What every teacher should know about the functions of learning in the human brain. White, William F. // Education;Winter96, Vol. 117 Issue 2, p290 

    Examines the significance of knowledge pertaining to the functions of learning in the human brain. Domains of knowledge and interactions; Neurophysiology of the brain and its function in learning; Storage and retrieval in the long term memory; Formation of meanings in the brain; Position...

  • Translating Principles of Neural Plasticity Into Research on Speech Motor Control Recovery and Rehabilitation. Ludlow, Christy L.; Hoit, Jeannette; Kent, Raymond; Ramig, Lorraine O.; Shrivastav, Rahul; Strand, Edythe; Yorkston, Kathryn; Sapienza, Christine M. // Journal of Speech, Language & Hearing Research;Feb2008, Vol. 51 Issue 1, pS240 

    Purpose: To review the principles of neural plasticity and make recommendations for research on the neural bases for rehabilitation of neurogenic speech disorders. Method: A working group in speech motor control and disorders developed this report, which examines the potential relevance of basic...

  • Your Brain on Yoga. McCall, Timothy // Yoga + Joyful Living;Fall2009, Issue 107, p9 

    The article focuses on how yoga affects the structure of brain. The brain's ability to reshape itself is termed as neuroplasticity. Some recent research has shown that even aging brains can add new neurons and this fact has been taught by yogis for millennia. They say that the structure of a...

  • GROWING YOUR GREY MATTER: Our brain is plastic-and adaptable. Francis, Charlotte // Alive: Canada's Natural Health & Wellness Magazine;Apr2011, Issue 342, p71 

    The article highlights that the human brain is plastic and adaptable, and therefore can continue to grow and support learning of new skills and cognitive abilities into old age. It cites a study by neuroscientist Michael Merzenich, who reports that appropriate training can reverse age related...

  • Mucking up movements. Malenka, Robert C. // Nature;11/17/1994, Vol. 372 Issue 6503, p218 

    Investigates the link between activity-dependent changes in synaptic strength and learning and memory. Synaptic step unique to synaptic plasticity; Two classes of glutamate receptors; Occurrence of synaptic plasticity in brain areas lacking in glutamate receptors; Hippocampal-dependent learning...

  • COMMENTARIES. Colombo, Roberto // International Journal of Therapy & Rehabilitation;Feb2009, Vol. 16 Issue 2, p84 

    The article presents an investigation on the amount of time that patients after stroke effectively spend in individual physiotherapy and circuit class therapy. The discussion is depicted on a study which has pointed that the learning phenomenon results in neuroplasticityin both lesioned and...

  • Multiple Realizability, Identity Theory, and the Gradual Reorganization Principle. Barrett, David A. // British Journal for the Philosophy of Science;Jun2013, Vol. 64 Issue 2, p325 

    In the literature on multiple realizability and the identity theory, cases of neural plasticity have enjoyed a very limited role. The present article attempts to remedy this small influence by arguing that clinical and experimental evidence of quite extensive neural reorganization offers...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics