HPV Infection in Men

Winslow, Dean L.
January 2008
Travel Medicine Advisor;Jan2008, Vol. 18 Issue 1, p3
These three studies published back to back in the Journal of Infectious Diseases serve to better characterize HPV infection in heterosexual men. The first study from the group in Seattle followed a cohort of 240 heterosexually-active male university students from 2003 until 2006 and obtained genital samples at 4-month intervals for HPV-DNA analysis by PCR while the students maintained a web-based log of their sexual activity. By 24 months, the cumulative incidence of new infection with HPV was 62.4%. Report of a new sex partner in the preceding 8 months approximately doubled the relative risk of acquiring infection. A history of smoking increased the risk of acquiring infection with HPV by a factor of 1.6. The second study conducted under CDC auspices recruited 463 men 18-40 years old from Tucson and Tampa and also used HPV detection by PCR and completion of a self-administered questionnaire at one time point only. Prevalence in this slightly older population of HPV infection of any type was 65.4%, 29.2% for oncogenic types, and 36.3% for non-oncogenic types. Lifetime and recent number of Femme Sex Partners (FSPs), condom use, and smoking were modifiable risk factors associated with HPV infection. The third paper was a more in-depth analysis of technical factors associated with detection of HPV DNA derived from the dataset of the CDC study described above. Bottom line results from this study demonstrated that, at minimum, the penile shaft and glans penis/coronal sulcus should be sampled in heterosexual men, and that for optimal detection, scrotal, perianal and anal samples should be obtained as well.


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