Rheumatoid Arthritis Patients with Sjogren's Syndrome are More Prone to Depression than Patients with Rheumatoid Arthritis or Sjogren's Syndrome Alone

Miwa, Yusuke; Hosaka, Michio; Wakabayashi, Kunibobu; Odai, Tsuyoshi; Isozaki, Takeo; Matsunawa, Mizuho; Yajima, Nobuyuki; Shiozawa, Fumitaka; Hanaoka, Ryosuke; Negishi, Masao; Ide, Hirotsu; Kasama, Tsuyoshi; Adachi, Mitsuru
February 2008
Current Rheumatology Reviews;2008, Vol. 4 Issue 1, p46
Academic Journal
Although depression is known to be an important complication in patients with rheumatoid arthritis (RA) or Sjogren's syndrome (SS), at present little is known about the mental states of RA patients who also have SS. To address that issue, we recently used a standardized questionnaire, the self-rating depression scale (SDS), to compare the mental states of patients with RA alone and those with RA complicated by SS. There were no significant differences between the two groups with respect to age, sex, arthralgia, patient global assessment or dosage of steroid. On the other hand, the SDS scores of RA patients with SS were significantly higher than those of RA patients without SS. Among the twenty items on the SDS questionnaire, RA patients with SS complained of “constipation” significantly more often than RA patients without SS. Collectively, our findings suggest SS exacerbates depression in RA patients. In discussing our findings, we describe the features of the depression seen in patients with RA, SS and RA with secondary SS, and make comparisons among these three groups.


Related Articles

  • Sjögren's Syndrome (Sicca Syndrome): Current Issues. Moutsopoulos, Haralampos M.; Chused, Thomas M.; Mann, Dean L.; Klippel, John H.; Fauci, Anthony S.; Frank, Michael M.; Lawley, Thomas J.; Hamburger, Max I. // Annals of Internal Medicine;Feb80 Part 1, Vol. 92 Issue 2, p212 

    Discusses several issues concerning the Sj ö gren's syndrome. Association of of Sj ö gren's syndrome with other autoimmune diseases; Cases of malignancy among female patients with Sj ö gren's syndrome; Clinical differences of Sj ö gren's syndrome in the presence and absence of...

  • Emerging biological therapies in primary Sjögren's syndrome. Ramos-Casals, M.; Brito-Zerón, P. // Rheumatology;Sep2007, Vol. 46 Issue 9, p1389 

    Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects the exocrine glands and usually presents as persistent dryness of the mouth and eyes. SS primarily affects white perimenopausal women, with an incidence of 4–5 cases per 100 000. Recent studies have analysed...

  • Primary Sjogren’s syndrome with anticentromere antibodies—a clinically distinct subset. Gulati, Dhiraj; Kushner, Irving; File, Elizabeth; Magrey, Marina // Clinical Rheumatology;Jul2010, Vol. 29 Issue 7, p789 

    Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disorder of the exocrine glands. The diagnosis is largely based on keratoconjunctivitis sicca and xerostomia in the presence of anti-SS-A and/or SS-B antibodies. Anticentromere antibodies (ACA) have occasionally been reported in...

  • The co-occurrence of Hashimoto thyroiditis in primary Sjogren's syndrome defines a subset of patients with milder clinical phenotype. Caramaschi, Paola; Biasi, Domenico; Caimmi, Cristian; Scambi, Cinzia; Pieropan, Sara; Barausse, Giovanni; Adami, Silvano // Rheumatology International;May2013, Vol. 33 Issue 5, p1271 

    To evaluate in a cohort of 100 consecutive patients affected by primary Sjogren's syndrome (pSS) the incidence of Hashimoto thyroiditis (HT) and to compare the clinical features and the laboratory parameters of patients affected by pSS with and without concomitant HT. In 100 consecutive patients...

  • A primary Sjögren’s syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis. Soy, Mehmet; Pamuk, Ömer Nuri; Gerenli, Murat; Çelik, Yahya // Rheumatology International;Nov2005, Vol. 26 Issue 1, p86 

    Although renal tubular acidosis (RTA), secondary to autoimmune interstitial nephritis, develops in a large proportion of patients with Sjögren’s syndrome (SS), most of the subjects are asymptomatic. Here, we shall present a 39-year-old female patient who came to us with hypokalemic...

  • Perfil clínico y epidemiológico de pacientes con síndrome de Sjögren concomitante a artritis reumatoide. Martínez Sánchez, Lina María; Cardona Velez, Jonathan; Vargas Grisales, Natalia; Rojas Londoño, Jennifer; Rodríguez Gázquez, María de los Ángeles // MedUNAB;ago-nov2013, Vol. 16 Issue 2, p65 

    Sjogren's syndrome is a chronic autoimmune disease where the exocrine glands of the body. Sjogren's syndrome is characterized by xerostomia and xerophthalmia. Objective. To describe the clinical and epidemiological profile of patients with Sjogren's syndrome concomitant to rheumatoid arthritis...

  • Ocular Manifestations of Autoimmune Disease. Patel, Sayjal J.; Lundy, Diane C. // American Family Physician;9/15/2002, Vol. 66 Issue 6, p991 

    Discusses the ocular effects of autoimmune disorders. Ocular manifestations of rheumatoid arthritis; Information on the keratoconjunctivitis sicca in Sjögren's syndrome; Details of the afferent and efferent disorders in multiple sclerosis.

  • Persistent dry mouth. Porter, Stephen; Hegarty, Anne // Pulse;4/8/2002, Vol. 62 Issue 14, p47 

    Presents the case of a patient who was diagnosed with secondary Sj ö gren's syndrome. Medical history of the patient; Signs and symptoms of the disease; Treatment for the condition.

  • Depression als Systemeffekt bei rheumatoider Arthritis. Englbrecht, M.; Wendler, J.; Alten, R. // Zeitschrift für Rheumatologie;Dec2012, Vol. 71 Issue 10, p859 

    The social recognition of depression in general and as a comorbidity in illnesses such as rheumatoid arthritis (RA) has essentially changed in recent years. Previous studies have shown that the occurrence of depression in RA patients is closely related to the individual ways of coping with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics