Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance

Straczkowski, Marek; Kowalska, Irina; Nikolajuk, Agnieszka; Dzienis-Straczkowska, Stella; Szelachowska, Malgorzata; Kinalska, Ida
January 2003
Cardiovascular Diabetology;2003, Vol. 2, p5
Academic Journal
Background: Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods: A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/m²), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results: The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-8OGTT) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-8OGTT was positively related to postload glucose and negatively to insulin sensitivity. Conclusion: Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT).


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