TITLE

Monocyte matrix metalloproteinase production in Type 2 diabetes and controls -- a cross sectional study

AUTHOR(S)
Baugh, Mark D.; Gavrilovic, Jelena; Davies, Isabel R.; Hughes, David A.; Sampson, Mike J.
PUB. DATE
January 2003
SOURCE
Cardiovascular Diabetology;2003, Vol. 2, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte — macrophages. As MMP expression can be promoted by the modified lipoproteins, oxidative stress and hyperglycaemia that characterises Type 2 diabetes, we hypothesised that peripheral monocytes in these patients, exposed to these factors in vivo, would demonstrate increased MMP production compared to controls. Methods: We examined peripheral venous monocyte expression of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 18 controls and 22 subjects with Type 2 diabetes and no previous cardiovascular complications. Results: No significant difference in MMP-1, 3 or 9 or TIMP-1 production was observed between control and diabetes groups. Conclusions: Monocyte MMP-1, 3, and 9, and TIMP-1, production are not abnormal in Type 2 diabetes. This data cannot be extrapolated to monocyte — macrophage behaviour in the vessel wall, but it does suggest MMP and TIMP-1 expression prior to monocyte infiltration and transformation are not abnormal in Type 2 diabetes.
ACCESSION #
28683668

 

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