How hyperglycemia promotes atherosclerosis: molecular mechanisms
- Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Kucharska-Newton, Anna M.; Monda, Keri L.; Bielinski, Suzette J.; Boerwinkle, Eric; Rea, Thomas D.; Rosamond, Wayne D.; Pankow, James S.; Köttgen, Anna; Heiss, Gerardo; North, Kari E. // Journal of Obesity;2010, p1
We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort. Cox proportional hazard regression...
- Role of Hyperglycaemia in Pathogenesis of Diabetic Cardiovascular Disease. Zervou, Sevasti; Khan, Michael // Vascular Disease Prevention;Apr2007, Vol. 4 Issue 2, p125
The accumulated wisdom of the last decade has fuelled a view of diabetes as an unusually severe form of cardiovascular disease (CVD) with a poor prognosis. Diabetic patients expect an up to 3-fold increase in coronary heart disease (CHD) events, independent of other traditional CVD risk factors,...
- Silent coronary artery disease in type 2 diabetes mellitus: the role of Lipoprotein(a), homocysteine and apo(a) polymorphism. Gazzaruso, Carmine; Garzaniti, Adriana; Giordanetti, Stefano; Falcone, Colomba; Fratino, Pietro // Cardiovascular Diabetology;2002, Vol. 1, p5
Background: There is little data on the relationship between novel cardiovascular risk factors and silent coronary artery disease (CAD) in diabetic patients. We investigated whether Lipoprotein(a), homocysteine and apolipoprotein(a) polymorphism are associated with angiographically assessed...
- Diabetes has a greater effect on mortality in women with CHD. // Geriatrics;Dec93, Vol. 48 Issue 12, p58
Reports on the findings of a study regarding the effects of diabetes on patients with coronary heart disease. `Sex differences in the impact of coexistent diabetes on survival in patients with coronary heart disease,' by Y Liao, RS Cooper, JK Ghali, et al.
- Agreement between Framingham Risk Score and United Kingdom Prospective Diabetes Study Risk Engine in Identifying High Coronary Heart Disease Risk in North Indian Population. Bansal, Dipika; Nayakallu, Ramya S. R.; Gudala, Kapil; Vyamasuni, Rajavikram; Bhansali, Anil // Diabetes & Metabolism Journal;Aug2015, Vol. 39 Issue 4, p321
Background: The aim of the study is to evaluate the concurrence between Framingham Risk score (FRS) and United Kingdom Prospective Diabetes Study (UKPDS) risk engine in identifying coronary heart disease (CHD) risk in newly detected diabetes mellitus patients and to explore the characteristics...
- Lung Function and Risk of Type 2 Diabetes and Fatal and Nonfatal Major Coronary Heart Disease Events: Possible Associations With Inflammation. WANNAMETHEE, S. GOYA; SHAPER, A. GERALD; RUMLEY, ANN; SATTAR, NAVEED; WHINCUP, PETER H.; THOMAS, MARY C.; LOWE, GORDON D. // Diabetes Care;Sep2010, Vol. 33 Issue 9, p1990
OBJECTIVE -- We prospectively examined the relationship between lung function and risk of type-2 diabetes and fatal and nonfatal coronary heart disease (CHD) events and investigated the hypothesis that inflammation may underlie these associations. RESEARCH DESIGN AND METHODS-- A prospective...
- Progression of microalbuminuria to proteinuria in type 1 diabetes. Warram, James H.; Scott, Laura J.; Hanna, Linda S.; Wantman, Michael; Cohen, Shmuel E.; Laffel, Lori M.B.; Ryan, Louise; Krolewski, Andrzej S. // Diabetes;Jan2000, Vol. 49 Issue 1, p94
Studies the dose-response relationship between exposure to hyperglycemia and progression of microalbuminuria to overt proteinuria of individuals with type 1 diabetes. Incidence rate of progression; Examination of the dose-response curve; Reducing the risk of progression.
- Diabetes und Demenz. Bahrmann, A.; Bahrmann, P.; Kubiak, T.; Kopf, D.; Oster, P.; Sieber, C.C.; Daniel, W.G. // Zeitschrift fÃ¼r Gerontologie und Geriatrie;Jan2012, Vol. 45 Issue 1, p17
Diabetes mellitus is a known risk factor for cognitive dysfunction and dementia. Chronic hyperglycemia, genetic predisposition, arterial hypertension, hyperlipoproteinemia, micro- and macrovascular diseases, and depression play a major role in the development of cognitive dysfunction. Both...
- Parental History of Diabetes Modifies the Association Between Abdominal Adiposity and Hyperglycemia. Van Dam, Rob M.; Boer, Jolanda M.A.; Feskens, Edith J.M.; Seidell, Jaap C. // Diabetes Care;Aug2001, Vol. 24 Issue 8, p1454
Presents information on a study which examined whether the association between abdominal obesity and hyperglycemia differs according to the presence of a parental history of diabetes. Research design and methods; Factors associated with hyperglycemia; Results and conclusion.