Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes

Humpert, Per M.; Djuric, Zdenka; Kopf, Stefan; Rudofsky, Gottfried; Morcos, Michael; Nawroth, Peter P.; Bierhaus, Angelika
January 2007
Cardiovascular Diabetology;2007, Vol. 6, p9
Academic Journal
Background: Total circulating soluble receptor for advanced glycation endproducts (sRAGE) and a more defined endogenous secretory splice variant of the receptor (esRAGE) were shown to be associated with different markers of cardiovascular risk in patients with diabetes. Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head-to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria. Methods: sRAGE and esRAGE were studied in plasma of 110 T2DM patients using enzyme-linked immunosorbant assays (ELISA) detecting either sRAGE or esRAGE only. Both sRAGE and esRAGE were compared with regard to applicability as markers for vascular disease and glucose control in T2DM. Results: In bivariate analysis, sRAGE correlated with age (R = 0.22, p = 0.02) and the 24 hour albumin excretion rate (R = 0.18, p = 0.05), while esRAGE correlated positively with age only (R = 0.23, p = 0.02). In contrast to previous reports, neither sRAGE nor esRAGE correlated with glucose control or intima-media-thickness (IMT) as a predictor of macrovascular disease. In multivariate regression models, the associations between sRAGE and albuminuria as well as esRAGE and age were shown to be independent of glucose control, diabetes duration, body-mass index, glomerular filtration rate, blood pressure and gender. Conclusion: This is the first study comparing sRAGE and esRAGE as markers of vascular complications in patients with T2DM. sRAGE but not esRAGE is independently associated with albuminuria in these patients while neither sRAGE nor esRAGE are associated with markers of glucose control or macrovascular disease.


Related Articles

  • Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes. Young Min Cho; Byung-Soo Youn; Hyewon Lee; Namseok Lee; Sung-Shik Min; Soo Heon Kwak; Hong Kyu Lee; Kyong Soo Park // Diabetes Care;Nov2006, Vol. 29 Issue 11, p2457 

    OBJECTIVE -- The dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes. Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance. Here, we examined the relation...

  • Thrombospondin-1 in Patients with Diabetic Nephropathy. Abdelwhab, Saeed; Fooda, Osman; Abdelmaksoud, Sahar // Kidney;Sep2010, Vol. 19 Issue 5, p229 

    Thrombospondin-1 (TSP-1), a potent antiangiogenic and proatherogenic protein, has been implicated in the development of several vascular diabetic complications. The aim of the study is to find the role of TSP-1 in diabetic nephropathy. We investigated serum TSP-1 in 30 patients with type 2...

  • DIABETIC PATIENTS; STUDY OF INFLAMMATORY MARKERS. Khan, Shakir; Yousaf, Muhammad Javad; Shabbir, Faizania; Rajput, Tausif Ahmed // Professional Medical Journal;2014, Vol. 21 Issue 2, p270 

    Objectives: Inflammation is the one of the major causes for development of type 2 diabetes mellitus and its complications. In this study, association between inflammation and type 2 diabetes mellitus was studied by measuring various inflammatory markers (soluble vascular cell adhesion molecules...

  • Increased urinary angiotensinogen precedes the onset of albuminuria in normotensive type 2 diabetic patients. Zhen Zhuang; Qiong Bai; Lata, A.; Yaoxian Liang; Danxia Zheng; Yue Wang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 9, p11464 

    It was previously reported that intrarenal renin angiotensin system (RAS) plays a pivotal role in the onset and progression of diabetic nephropathy (DN). Urinary angiotensinogen (UAGT) was employed as a special index of the intrarenal RAS status and enhanced significantly at a very early stage...

  • Inflammatory Markers and Haptoglobin Polymorphism in Saudi with Non-insulin-dependent Diabetes Mellitus. Mohieldein, Abdelmarouf; Alzohairy, Mohammad; Hasan, Marghoob; Khan, Amjad A. // Global Journal of Health Science;Jan2013, Vol. 5 Issue 1, p135 

    Objectives: Haptoglobin (Hp) polymorphism associated with clinical evolution of several inflammatory diseases and considered as a predictive factor for development of diabetes complications. We designed the present study to investigate the frequency distribution of Hp phenotypes among Saudi with...

  • No Relationship between Osteocalcin and the Microvascular Complications of Type 2 Diabetes. Küçükler, Ferit Kerim; Bardak, Simge; Çelik, Tuğrul; Tütüncü, Yasemin; Akbaba, Gülhan; Işık, Serhat; Karaahmetoğlu, Selma; Eskioğlu, Erdal; Berker, Dilek; Güler, Serdar // Turkish Journal of Endocrinology & Metabolism;12/1/2014, Vol. 18 Issue 4, p126 

    Purpose: Osteocalcin, one of the osteoblast-specific proteins is produced and secreted by osteoblasts. Although osteocalcin has been thought to play a role only in bone formation, recent studies have shown that it also enhances insulin sensitivity and insulin secretion from pancreatic beta...

  • Relationship Between Plasma Mid-Regional Pro-Adrenomedullin Levels and Microvascular Complications in Type 2 Diabetes. Yong Mong Bee; Nils G. Morgenthaler; Su Chin Ho; E. Shyong Tai // Diabetes;Jun2007 Supplement 1, Vol. 56, pA672 

    Adrenomedullin is a vasodilator peptide and plasma levels are elevated in a variety of pathologic states. It is less clear whether the microvascular complications of diabetes are associated with elevations of plasma ADM. Reliable quantification has been hampered by the short half-life, the...


    Microalbuminuria represents the earliest clinical evidence of diabetic nephropathy. Early detection of microalbuminuria and early control of diabetes retards the development of structural changes in early diabetic nephropathy. This study aimed to determine the prevalence and correlation of...

  • Anticardiolipin Antibodies in Patients with Type 2 Diabetes Mellitus. Colvo-Romero, José María; Lima-Rodríguez, Esther María // Clinical Medicine & Research;Sep2009, Vol. 7 Issue 3, p93 

    Background: There is controversy about an increased prevalence of antiphospholipid antibodies in diabetic patients. The possible implications are little known. Methods: We prospectively studied all consecutive outpatients with type 2 diabetes mellitus (DM) attended to in an Internal Medicine...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics