Pro-oxidant effect of α-tocopherol in patients with Type 2 Diabetes after an oral glucose tolerance test -- a randomised controlled trial

Winterbone, Mark S.; Sampson, Mike J.; Saha, Shikha; Hughes, Jackie C.; Hughes, David A.
January 2007
Cardiovascular Diabetology;2007, Vol. 6, p8
Academic Journal
Background: As a part of a larger study investigating the effects of α-tocopherol on gene expression in type 2 diabetics we observed a pro-oxidant effect of α-tocopherol which we believe may be useful in interpreting outcomes of large intervention trials of α-tocopherol. Methods: 19 type 2 diabetes subjects were randomised into two groups taking either 1200 IU/day of α-tocopherol or a matched placebo for 4 weeks. On day 0 and 29 of this study oxidative DNA damage was assessed in mononuclear cells from fasted blood samples and following a 2 h glucose tolerance test (GTT). Results: On day 0 there was no significant difference in oxidative DNA damage between the two groups or following a GTT. On day 29 there was no significant difference in oxidative DNA damage in fasted blood samples, however following a GTT there was a significant increase in oxidative DNA damage in the a-tocopherol treatment group. Conclusion: High dose supplementation with a-tocopherol primes mononuclear cells from patients with type 2 diabetes for a potentially damaging response to acute hyperglycaemia.


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