TITLE

Pro-oxidant effect of α-tocopherol in patients with Type 2 Diabetes after an oral glucose tolerance test -- a randomised controlled trial

AUTHOR(S)
Winterbone, Mark S.; Sampson, Mike J.; Saha, Shikha; Hughes, Jackie C.; Hughes, David A.
PUB. DATE
January 2007
SOURCE
Cardiovascular Diabetology;2007, Vol. 6, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: As a part of a larger study investigating the effects of α-tocopherol on gene expression in type 2 diabetics we observed a pro-oxidant effect of α-tocopherol which we believe may be useful in interpreting outcomes of large intervention trials of α-tocopherol. Methods: 19 type 2 diabetes subjects were randomised into two groups taking either 1200 IU/day of α-tocopherol or a matched placebo for 4 weeks. On day 0 and 29 of this study oxidative DNA damage was assessed in mononuclear cells from fasted blood samples and following a 2 h glucose tolerance test (GTT). Results: On day 0 there was no significant difference in oxidative DNA damage between the two groups or following a GTT. On day 29 there was no significant difference in oxidative DNA damage in fasted blood samples, however following a GTT there was a significant increase in oxidative DNA damage in the a-tocopherol treatment group. Conclusion: High dose supplementation with a-tocopherol primes mononuclear cells from patients with type 2 diabetes for a potentially damaging response to acute hyperglycaemia.
ACCESSION #
28682840

 

Related Articles

  • Effect Of Vitamin On Malondialdehyde And Glutathione Levels In Type 2 Diabetic Nigerians. Ifeoma, N. Nweke; Obioma, C. Cohaeri; Chinyere, C. Cezeala // Internet Journal of Pharmacology;2009, Vol. 7 Issue 1, p1 

    The effect of modest supplementation of vitamin E (α-tocopherol) on lipid peroxidation product, malondialdehyde (MDA), and reduced glutathione (GSH), was investigated in type 2 diabetic Nigerian patients. Written and informed consent to participate in this study was obtained from 80 type 2...

  • α-Tocopherol Supplementation Decreases Plasminogen Activator Inhibitor-1 and P-Selectin Levels in Type 2 Diabetic Patients. Devaraj, Sridevi; Cabo Chan Jr., Alberto V.; Jialal, Ishwarlal // Diabetes Care;Mar2002, Vol. 25 Issue 3, p524 

    Focuses on a study which examined the effect of natural antioxidant α-tocopherol supplementation on markers of thrombosis, plasminogen activator inhibitor-1 and soluble P-selectin in type 2 diabetics. Research design and methods; Results; Conclusions.

  • Demographic, Environmental, and Genetic Predictors of Metabolic Side Effects of Hydrochlorothiazide Treatment in Hypertensive Subjects Maitland-van der Zee, Anke-Hilse; Turner, Stephen T.; Schwartz, Gary L.; Chapman, Arlene B.; Klungel, Olaf H.; Boerwinkle, Eric // American Journal of Hypertension;Aug2005, Vol. 18 Issue 8, p1077 

    Background: Thiazide diuretics are recommended for first-line treatment of hypertension. Although considered safe and effective, their use is associated with dyslipidemia, hyperglycemia, and an increased risk of developing type 2 diabetes. The aim of this study was to characterize...

  • Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State. Erol, A. // Current Molecular Medicine;Apr2010, Vol. 10 Issue 3, p321 

    Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. DNA damage in response to genotoxic and oncogenic stresses activate the tumor suppressor pathways initiating DNA damage response (DDR). One of the cellular fates in...

  • PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases. Chao-Qiang Lai; Tucker, Katherine L.; Parnell, Laurence D.; Adiconis, Xian; García-Bailo, Bibiana; Griffith, John; Meydani, Mohsen; Ordovás, José M. // Diabetes;Apr2008, Vol. 57 Issue 4, p809 

    OBJECTIVE--Individuals with type 2 diabetes exhibit higher DNA damage and increased risk of cardiovascular disease (CVD). However, mechanisms underlying the association between DNA damage and development of type 2 diabetes and CVD are not understood. We sought to link peroxisome...

  • Biomarkers of Oxidative DNA Damage and Soluble Fas/Fas Ligand in Type 2 Diabetic Patients. Mahfouz, Mohamed H.; Emara, Ibrahim A.; Omar, Ghada A. // American Journal of Applied Sciences;Apr2012, Vol. 9 Issue 4, p450 

    Problem statement: Involvement of oxidative stress in the pathogenesis of diabetic complications has been proposed. 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. Apoptosis via Fas/Fas Ligand (FasL) interactions...

  • Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes. Sampson, Mike J.; Winterbone, Mark S.; Hughes, Jackie C.; Dozio, Nicoletta; Hughes, David A. // Diabetes Care;Feb2006, Vol. 29 Issue 2, p283 

    OBJECTIVE -- Telomeres are DNA sequences necessary for DNA replication, which shorten at cell division at a rate related to levels of oxidative stress. Once shortened to a critical length, cells are triggered into replicative senescence. Type 2 diabetes is associated with oxidative DNA damage,...

  • Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study. Xiang Feng; Tucker, Katherine L.; Parnell, Laurence D.; Jian Shen; Yu-Chi Lee; Ordovás, José M.; Wen-Hua Ling; Chao-Qiang Lai // Asia Pacific Journal of Clinical Nutrition;Mar2013, Vol. 22 Issue 1, p150 

    Objective: Published data concerning associations between 1RS1 variants and type 2 diabetes and related traits have been inconsistent. We examined the relationship between common variants in IRS1, type 2 diabetes, and related traits including insulin resistance, hyperglycemia and DNA damage in...

  • Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy. Waris, Sahar; Winklhofer-Roob, Brigitte M.; Roob, Johannes M.; Fuchs, Sebastian; Sourij, Harald; Rabbani, Naila; Thornalley, Paul J. // Journal of Diabetes Research;4/9/2015, Vol. 2015, p1 

    Aim. The aim of this study was to assess the changes of markers of DNA damage by glycation and oxidation in patients with type 2 diabetes and the association with diabetic nephropathy. Methodology. DNA oxidation and glycation adducts were analysed in plasma and urine by stable isotopic dilution...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics