Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration

Misso, N. L. A.; Petrovic, N.; Grove, C.; Celenza, A.; Brooks-Wildhaber, J.; Thompson, P. J.
January 2008
Thorax;Jan2008, Vol. 63 Issue 1, p21
Academic Journal
Background: Secretory phospholipases A2 (sPLA2) have functions relevant to asthmatic inflammation, including eicosanoid synthesis and effects on dendritic cells and T cells. The aim of this study was to measure sPLA2 activity in patients with stable and acute asthma and to assess potential associations with body mass index (BMI), and plasma cholesterol and vitamin C concentrations. Methods: Plasma sPLA2 activity and concentrations of cholesterol and vitamin C were measured in 23 control subjects and 61 subjects with stable asthma (42 mild to moderate, 19 severe). In addition, sPLA2 activity was measured in 36 patients experiencing acute asthma and in 22 of these patients after recovery from the acute attack. Results: sPLA2 activity was not significantly greater in severe (499.9 U; 95% confidence interval (CI) 439.4 to 560.4) compared with mild to moderate asthmatic subjects (464.8; 95% CI 425.3 to 504.3) or control subjects (445.7; 95% CI 392.1 to 499.4), although it was higher in patients with acute asthma (581.6; 95% CI 541.2 to 622.0; p<0.001). Male gender, high plasma cholesterol, increased BMI and atopy were associated with increased sPLA2 activity, while plasma vitamin C was inversely correlated with sPLA2 activity in patients with stable asthma and in control subjects. There were significant interactions between gender and plasma cholesterol and between gender and vitamin C in relation to sPLA2 activity. Conclusions: Plasma sPLA2 may provide a biological link between asthma, inflammation, increased BMI, lipid metabolism and antioxidants. Interactions among these factors may be pertinent to the pathophysiology and increasing prevalence of both asthma and obesity.


Related Articles

  • Acute cholesterol depletion leads to net loss of the organic osmolyte taurine in Ehrlich Lettré tumor cells. Villumsen, Kasper Rømer; Duelund, Lars; Lambert, Ian Henry // Amino Acids;Nov2010, Vol. 39 Issue 5, p1521 

    In mammalian cells, the organic osmolyte taurine is accumulated by the Na-dependent taurine transporter TauT and released though the volume- and DIDS-sensitive organic anion channel. Incubating Ehrlich Lettré tumor cells with methyl-β-cyclodextrin (5 mM, 1 h) reduces the total cholesterol...

  • Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid. Kohjimoto, Yasuo; Honeyman, Thomas W.; Jonassen, Julie; Gravel, Kathryn; Kennington, Lori; Scheid, Cheryl R.; Kohjimoto, Y; Honeyman, T W; Jonassen, J; Gravel, K; Kennington, L; Scheid, C R // Kidney International;Aug2000, Vol. 58 Issue 2, p638 

    Background: Exposure to high levels of oxalate induces oxidant stress in renal epithelial cells and produces diverse changes in cell function, ranging from cell death to cellular adaptation, as evidenced by increased DNA synthesis, cellular proliferation, and induction of genes...

  • Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation. Bate, Clive; Tayebi, Mourad; Williams, Alun // BMC Biology;2008, Vol. 6, Special section p1 

    Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation of PrPSc within the brain leads to neurodegeneration...

  • The Relationship between Serum YKL-40 Levels and Severity of Asthma. Duru, Serap; Yüce, Gülbahar; Ulasli, Sevinc Sarinc; Erdem, Melike; Kizilgün, Murat; Kara, Fatma; Sadık Ardic // Iranian Journal of Allergy, Asthma & Immunology;Sep2013, Vol. 12 Issue 3, p247 

    YKL-40 (chitinase-3-like-1) has been introduced as a marker of inflammation in asthma. The aim of this study was to determine the role of YKL-40 in asthma and to evaluate the relationship between YKL-40 and asthma severity. In the study, 60 non-smoker asthma patients without additional diseases...

  • ERS Congress 2013: Asthma control 'poor for years'. Robinson, Stephen // GP: General Practitioner;9/16/2013, p38 

    Almost half of patients do not have good asthma control a decade after diagnosis, research has shown.

  • Evaluation of lipoprotein-associated Phospholipase A2 in Healthy Chinese Han Adult Serum. Li-Min Feng; Guo-Fang Feng; Yu Chen // Lipids in Health & Disease;2014, Vol. 13 Issue 1, p1 

    Objective The aim of this study is to establish lipoprotein-associated phospholipase A2 (Lp-PLA2) reference intervals (RIs) in healthy Chinese Han adults as a clinical diagnostic indicator according to the Clinical and Laboratory Standards Institute (CLSI) C28-A3 guidelines. Design and methods...

  • Inhibition of type IIA secretory phopholipase A2 reduces cell-death of cardiomyocytes in acute myocardial infarction in rats. Vermond, R.A.; Van Dijk, A.; Krijnen, P.A.J.; Spreeuwenberg, M.D.; Visser, F.C.; Van Milligen, F.J.; Niessen, H.W.M. // European Journal of Heart Failure. Supplements;Jun2008, Vol. 7 Issue 1, p139 

    An abstract of the article "Inhibition of type IIA secretory phopholipase A2 reduces cell-death of cardiomyocytes in acute myocardial infarction in rats," by R. A. Vermond and colleagues is presented.

  • Key Role of Group V Secreted Phospholipase A2 in Th2 Cytokine and Dendritic Cell-Driven Airway Hyperresponsiveness and Remodeling. Henderson Jr, William R.; Ye, Xin; Lai, Ying; Ni, Zhanglin; Bollinger, James G.; Tien, Ying-Tzang; Chi, Emil Y.; Gelb, Michael H. // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Background: Previous work has shown that disruption of the gene for group X secreted phospholipase A2 (sPLA2-X) markedly diminishes airway hyperresponsiveness and remodeling in a mouse asthma model. With the large number of additional sPLA2s in the mammalian genome, the involvement of other...

  • CLINICAL CLIPS. Mintz, Matthew; Russell, John J. // Patient Care for the Nurse Practitioner;Oct2007, Vol. 10 Issue 10, p12 

    The article discusses several studies related to medicine. These include research being done on the relationship of body mass index with asthma indicators in Head Start children, and on a new criterion by which to discriminate between patients with moderate allergic rhinitis and patients with...


Read the Article


Sign out of this library

Other Topics