TITLE

Gender influence on the diagnostic accuracy of 64- slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease

AUTHOR(S)
Pundziute, G.; Schuijf, J. D.; Jukema, J. W.; van Werkhoven, J. M.; Boersma, E.; de Roos, A.; van der Wall, E. E.; Bax, J. J.
PUB. DATE
January 2008
SOURCE
Heart;Jan2008, Vol. 94 Issue 1, p48
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To compare the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography between female and male patients using conventional coronary angiography as the reference standard. Design: Diagnostic accuracy study. Setting: University hospital. Patients: 103 consecutive patients (51 men, 52 women, mean (SD) age 60 (10) years) with known and suspected coronary artery disease underwent 64-slice MSCT. Main outcome measures: Diagnostic accuracy of 64-slice MSCT to detect obstructive (⩾50% uminal narrowing) stenoses in men and women. Results: One male and two female patients were excluded from the analysis owing to non-diagnostic MSCT scans as a result of increased heart rate and breathing during the scan. Accordingly, on segmental level, 728/762 coronary segments were of sufficient quality in women (96% (95% Cl 95% to 97%)) and 704/723 segments were interpretable in men (97% )95% Cl 96% to 98%)). In the remaining 100 patients included in the further analyses, the sensitivity and specificity on a segmental level in women and men were 85% (95% Cl 75% to 95%) vs 85% )95% Cl 78% to 92%) and 99% (95% CI 98% to 100%) vs 99% (95% Cl 98% to 100%), respectively. On a patient level, the sensitivity in women and men was 95% )95% Cl 87% to 100%) vs 100%, specificity 93% (95% Cl 83% to 100%) vs 89% (95% Cl 74% to 100%), positive predictive value 91% (95% Cl 79% to 100%) vs 94% (95% CI 86% to 100%), and negative predictive value 96% (95% CI 89% to 100%) vs 100%, respectively. Conclusion: The findings confirm the high diagnostic accuracy of 64-slice MSCT coronary angiography in both male and female patients.
ACCESSION #
28658065

 

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