Bisphosphonate use and the risk of adverse jaw outcomes: A Medical Claims Study of 714,217 People

Cartsos, Vassiliki M.; Zhu, Shao; Zavras, Athanasios I.
January 2008
Journal of the American Dental Association (JADA);Jan2008, Vol. 139 Issue 1, p23
Academic Journal
The article discusses a study that explores the risk of osteonecrosis of the jaw (ONJ) among users of oral bisphosphonates (BPs) or the magnitude of the risk among users of intravenous (IV) BPs. Results reveal that oral administration of BPs reduces the risk of negative bone outcomes, while IV administration increases the risk of adverse jaw outcomes or surgery. The study also shows that patients receiving IV BPs has a fourfold increased risk of having inflammatory jaw conditions.


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