TITLE

Nucleocytoplasmic transport of proteins

AUTHOR(S)
Sorokin, A. V.; Kim, E. R.; Ovchinnikov, L. P.
PUB. DATE
December 2007
SOURCE
Biochemistry (00062979);Dec2007, Vol. 72 Issue 13, p1439
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In eukaryotic cells, the movement of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC)�a large protein complex spanning the nuclear envelope. The nuclear transport of proteins is usually mediated by a family of transport receptors known as karyopherins. Karyopherins bind to their cargoes via recognition of nuclear localization signal (NLS) for nuclear import or nuclear export signal (NES) for export to form a transport complex. Its transport through NPC is facilitated by transient interactions between the karyopherins and NPC components. The interactions of karyopherins with their cargoes are regulated by GTPase Ran. In the current review, we describe the NPC structure, NLS, and NES, as well as the model of classic Ran-dependent transport, with special emphasis on existing alternative mechanisms; we also propose a classification of the basic mechanisms of protein transport regulation.
ACCESSION #
28526844

 

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