Detection of emerging diseases in occupational health: usefulness and limitations of the application of pharmacosurveillance methods to the database of the French national occupational disease surveillance and prevention network (RNV3P)

Bonneterre, Vincent; Bicout, Dominique J.; Larabi, Linda; Bernardet, Cyril; Maitre, Anne; Tubert-Bitter, Pascale; de Gaudemaris, Régis
January 2008
Occupational & Environmental Medicine;Jan2008, Vol. 65 Issue 1, p32
Academic Journal
Objective: To test data mining methods used in pharmacosurveillance in order to identify potential emerging disease-nuisance associations in the national occupational disease surveillance and prevention network (RNV3P) database. Methods: Proportional reporting ratios (PRR) used in pharmacosurveillance were applied to detect disproportional reporting of disease-nuisance associations which are not compensated by the national social security system. Results: The 24 785 reports of the RNV3P were grouped into 1344 different disease-nuisance associations reported more than twice, of which 422 did not give entitlement to compensation by the social security system. Among these associations, 162 were potentially emergent and generated a signal, of which eight associations involve cancer. Conclusion: This work is the first stage of an exploratory investigation submitting the questions raised to experts and involving participants in the network in reflection on the hypotheses generated.


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