TITLE

Serum levels of beta-trace protein and its association to diuresis in haemodialysis patients

AUTHOR(S)
Thomas Gerhardt; Uwe Pöge; Birgit Stoffel-Wagner; Burkhard Klein; Hans-Ulrich Klehr; Tilman Sauerbruch; Rainer P. Woitas
PUB. DATE
January 2008
SOURCE
Nephrology Dialysis Transplantation;Jan2008, Vol. 23 Issue 1, p309
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Beta-trace protein (BTP) has been proposed as an alternative endogenous marker of the glomerular filtration rate. However, possible determinants of BTP in ESRD patients undergoing regular renal replacement therapy have not been evaluated. Methods. Serum levels of BTP, beta-2-microglobulin, creatinine and urea were analysed before and after dialysis treatment in 73 patients [haemodialysis (HD) n = 52; haemodiafiltration (HDF) n = 21]. Patients were categorized into four groups with residual diuresis (RD) n = 24), 0.5–1 l/day (group 2; n = 18), 1.1–1.5 l/day (group 3; n = 12) and >1.5 l/day (group 4; n = 19). Subsequently RD was compared to pre-treatment levels of BTP. Results. HD treatment did not affect BTP serum levels [pre-treatment 8.1 ± 4.1 mg/l (mean) vs post-treatment 7.7 ± 4.1 mg/l; −0.6 ± 16.1%; ns]. However, in 6 out of 21 patients undergoing HDF BTP levels were reduced by more than 20%. Overall, the resulting decrease in serum concentration was minuscule (9.6 ± 6.2 vs 8.3 ± 4.9 mg/l; −14 ± 21.9%; P = 0.03). BTP serum levels were tightly associated to RD of the four groups. Comparison of BTP levels showed significant differences between patients of groups 1 vs 3 and 4 as well as 2 vs 4. Conclusions. BTP serum levels may serve as a surrogate marker for residual renal function since HD and HDF do not exert clinical relevant alterations on them. Furthermore, BTP serum concentrations appear strongly associated to RD.
ACCESSION #
28387038

 

Related Articles

  • Serum levels of polyamines in patients with chronic renal failure. Saito, Akira; Takagi, Toyomi; Tai Gi Chung; Ohta, Kazuhiro // Kidney International Supplement;Dec1983, Issue 16, pS234 

    The article reports on the findings of a study which compares the results of a simultaneous determination of total putrescine, cadaverine, spermidine and spermine in the serum of chronic renal failure patients and those undergoing maintenance hemodialysis. The study also examines the possible...

  • Clinical outcomes in pediatric hemodialysis patients in the USA: lessons from CMS’ ESRD CPM Project. Neu, Alicia M.; Frankenfield, Diane L. // Pediatric Nephrology;Jul2009, Vol. 24 Issue 7, p1287 

    Although prospective randomized trials have provided important information and allowed the development of evidence-based guidelines in adult hemodialysis (HD) patients, with approximately 800 prevalent pediatric HD patients in the United States, such studies are difficult to perform in this...

  • Demographic trends in the Okinawa Dialysis Study (OKIDS) registry (1971–2000). Iseki, Kunitoshi; Tozawa, Masahiko; Iseki, Chiho; Takishita, Shuichi; Ogawa, Yoshihide // Kidney International;Feb2002, Vol. 61 Issue 2, p668 

    Demographic trends in the Okinawa Dialysis Study (OKIDS) registry (1971–2000).. Background: The clinical demographics of chronic dialysis patients are changing worldwide. However, long-term data from regional dialysis registries have not yet been analyzed and reported. Methods: The...

  • Survival advantage in Asian American end-stage renal disease patients1. Wong, Joyce S.; Port, Friedrich K.; Hulbert-Shearon, Tempie E.; Carroll, Caitlin E.; Wolfe, Robert A.; Agodoa, Lawrence Y.C.; Daugirdas, John T. // Kidney International;Jun1999, Vol. 55 Issue 6, p2515 

    Survival advantage in Asian American end-stage renal disease patients. Background. An earlier study documented a lower mortality risk for end-stage renal disease (ESRD) patients in Japan compared with the United States. We compared the mortality of Caucasian (white) and Asian American dialysis...

  • Relationship between dialysate oxidized protein and peritoneal membrane transport properties in patients on peritoneal dialysis. Sheron Latcha; Susana Hong; Nora Gibbons; Nina Kohn; Joseph Mattana // Nephrology Dialysis Transplantation;Oct2008, Vol. 23 Issue 10, p3295 

    Background. Increased levels of oxidized proteins have been reported in the serum of patients with end-stage renal disease, though little is known regarding the oxidized protein content of the dialysate in patients on peritoneal dialysis (PD) and no information is available as to how this may...

  • DIALYSIS PATIENTS; SURVIVAL DISTRIBUTION COMPARISON AND SURVIVAL ESTIMATION OF SOCIO-ECONOMIC AND LABORATORY VARIABLES. Shahzad, Isaac; Ahmad, Zahid // Professional Medical Journal;2014, Vol. 21 Issue 3, p465 

    Objectives: The objective of this study is to compare and analyze the survival distributions of the different categories of the socio-economic and laboratory variables of the ESRD patients. Through which we can see the difference between the categories of the individual categorical variable with...

  • Evaluation of Serum C-reactive Protein Level and its Related Factors in Hemodialysis Patients in Sari, Iran. Baradari, Afshin Gholipour; Zeydi, Amir Emami; Espahbodi, Fatemeh; Shahmohammadi, Soheyla // Pakistan Journal of Biological Sciences;5/15/2011, Vol. 14 Issue 10, p595 

    Chronic inflammation, as reflected by increased level of acute phase protein such as C-reactive Protein (CRP) is highly prevalent in hemodialysis patients. CRP is a strong predictor of overall and cardiovascular mortality and morbidity in hemodialysis patients. This research was conducted to...

  • Pathophysiology and clinical studies in CKD 5D.  // Nephrology Dialysis Transplantation;May2013 Supplement, Vol. 28 Issue suppl_1, pi249 

    No abstract available.

  • Low diastolic blood pressure, hypoalbuminemia, and risk of death in a cohort of chronic hemodialysis patients. Iseki, Kunitoshi; Miyasato, Fujihiko; Tokuyama, Kiyoyuki; Nishime, Keizo; Uehara, Hajime; Shiohira, Yoshiki; Sunagawa, Hiroshi; Yoshihara, Kunio; Yoshi, Shinichiro; Toma, Shigeki; Kowatari, Teruo; Wake, Toru; Oura, Takashi; Fukiyama, Koshiro // Kidney International;Apr1997, Vol. 51 Issue 4, p1212 

    In a previous report, we showed that nutritional status and especially serum albumin had great predictive value for death in chronic hemodialysis patients, whereas blood pressure did not. In the present study, we analyzed the causes of death in consideration of the relationship between serum...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics