The Mechanism of Axl-Mediated Ebola Virus Infection

Masayuki Shimojima; Yasuhiro Ikeda; Yoshihiro Kawaoka
November 2007
Journal of Infectious Diseases;11/15/2007 Supplement, Vol. 196 Issue 2, pS259
Academic Journal
We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the hysiological functions of Axl to enter cells.


Related Articles

  • Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor. Yoshikawa, S; Kukimoto-Niino, M; Parker, L; Handa, N; Terada, T; Fujimoto, T; Terazawa, Y; Wakiyama, M; Sato, M; Sano, S; Kobayashi, T; Tanaka, T; Chen, L; Liu, Z-J; Wang, B-C; Shirouzu, M; Kawa, S; Semba, K; Yamamoto, T; Yokoyama, S // Oncogene;1/3/2013, Vol. 32 Issue 1, p27 

    The epidermal growth factor receptor (EGFR) has an essential role in multiple signaling pathways, including cell proliferation and migration, through extracellular ligand binding and subsequent activation of its intracellular tyrosine kinase (TK) domain. The non-small cell lung cancer...

  • PKC and the control of localized signal dynamics. Rosse, Carine; Linch, Mark; Kermorgant, Stéphanie; Cameron, Angus J. M.; Boeckeler, Katrina; Parker, Peter J. // Nature Reviews Molecular Cell Biology;Feb2010, Vol. 11 Issue 2, p103 

    Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C...

  • Integrating signals from RTKs to ERK/MAPK. McKay, M. M.; Morrison, D. K. // Oncogene;5/14/2007, Vol. 26 Issue 22, p3113 

    Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular...

  • Receptor Tyrosine Kinase.  // Encyclopedic Reference of Molecular Pharmacology;2004, p807 

    A definition of the term "receptor tyrosine kinase" is presented. It refers to a family of membrane proteins which bind extracellular ligands like growth factors and insulin. The intracellular domain of the receptor catalyzes autophosphorylation and phosphorylation of specific substrates on...

  • Mutations in the Ligand-Binding Domain of the Kit Receptor: An Uncommon Site in Human Piebaldism. Fleischman, Roger A.; Gallardo, Teresa; Mi, Xiafang // Journal of Investigative Dermatology;Nov96, Vol. 107 Issue 5, p703 

    Heterozygous mutations in the gene for the Kit transmembrane receptor have been identified recently in human piebaldism and mouse "dominant spotting.'' Interestingly, all of the 14 known missense mutations that cause depigmentation in these species map to the tyrosine kinase domain of the...

  • Filoviruses: One of These Things is (not) Like the Other. Anthony, Scott M.; Bradfute, Steven B. // Viruses (1999-4915);2015, Vol. 7 Issue 10, p5172 

    The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus pathogenesis. However, in comparison, the...

  • Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas. Li, Lili; Ying, Jianming; Tong, Xin; Zhong, Lan; Su, Xianwei; Xiang, Tingxiu; Shu, Xingsheng; Rong, Rong; Xiong, Lei; Li, Hongyu; Chan, Anthony; Ambinder, Richard; Guo, Yajun; Tao, Qian // Cellular & Molecular Life Sciences;Jun2014, Vol. 71 Issue 11, p2179 

    Through subtraction of tumor-specific CpG methylation, we identified receptor tyrosine kinase-like orphan receptor 2 (ROR2) as a candidate tumor suppressor gene (TSG). ROR2 is a specific receptor or co-receptor for WNT5A, involved in canonical and non-canonical WNT signaling, with its role in...

  • Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-?, but not IFN-a, signaling. Takaoka, Akinori; Tanaka, Nobuyuki; Mitani, Yukiko; Miyazaki, Tadaaki; Fujii, Hodaka; Sato, Mitsuharu; Kovarik, Pavel; Decker, Thomas; Schlessinger, Joseph; Taniguchi, Tadatsugu // EMBO Journal;5/1/99, Vol. 18 Issue 9, p2480 

    Two distinct types of interferon, IFN-α/β and IFN-γ, commonly exhibit antiviral activities by transmitting signals to the interior of the cell via their homologous receptors. Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases...

  • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. Citri, Ami; Gan, Judith; Mosesson, Yaron; Vereb, Gyorgi; Szollosi, Janos; Yarden, Yosef // EMBO Reports;Dec2004, Vol. 5 Issue 12, p1165 

    ErbB-2/HER2 is an oncogenic tyrosine kinase that regulates a signalling network by forming ligand-induced heterodimers with several growth factor receptors of the ErbB family. Hsp90 and co-chaperones regulate degradation of ErbB-2 but not other ErbB members. Here, we report that the role of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics