PPARs in the Control of Uncoupling Proteins Gene Expression

Villarroya, Francesc; Iglesias, Roser; Giralt, Marta
January 2007
PPAR Research;2007 Special Issue 1, p1
Academic Journal
Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in the control of energy conversion in mitochondria. Experimental and genetic evidence relate dysfunctions of UCPs with metabolic syndrome and obesity. The PPAR subtypes mediate to a large extent the transcriptional regulation of the UCP genes, with a distinct relevance depending on the UCP gene and the tissue in which it is expressed. UCP1 gene is under the dual control of PPAR? and PPARa in relation to brown adipocyte differentiation and lipid oxidation, respectively. UCP3 gene is regulated by PPARa and PPARd in the muscle, heart, and adipose tissues. UCP2 gene is also under the control of PPARs even in tissues in which it is the predominantly expressed UCP (eg, the pancreas and liver). This review summarizes the current understanding of the role of PPARs in UCPs gene expression in normal conditions and also in the context of type-2 diabetes or obesity.


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