TITLE

DAS181, A Novel Sialidase Fusion Protein, Protects Mice from Lethal Avian Influenza H5N1 Virus Infection

AUTHOR(S)
Belser, Jessica A.; Xiuhua Lu; Szretter, Kristy J.; Xiaoping Jin; Aschenbrenner, Laura M.; Lee, Alice; Hawley, Stephen; Do Hyong Kim; Malakhov, Michael P.; Mang Yu; Fang Fang; Katz, Jacqueline M.
PUB. DATE
November 2007
SOURCE
Journal of Infectious Diseases;11/15/2007, Vol. 196 Issue 10, p1493
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Increasing resistance to currently available influenza antivirals highlights the need to develop alternate approaches for the prevention and/or treatment of influenza. DAS181 (Fludase), a novel sialidase fusion protein that enzymatically removes sialic acids on respiratory epithelium, exhibits potent antiviral activity against influenza A and B viruses. Here, we use a mouse model to evaluate the efficacy of DAS181 treatment against a highly pathogenic avian influenza H5N1 virus.Whenused to treat mice daily beginning 1 day before infection with A/Vietnam/1203/2004(H5N1) virus, DAS181 treatment at 1 mg/kg/day protected 100% of mice from fatal disease, prevented viral dissemination to the brain, and effectively blocked infection in 70% of mice. DAS181 at 1 mg/kg/day was also effective therapeutically, conferring enhanced survival of H5N1 virus- challenged mice when treatment was begun 72 h after infection. This notable antiviral activity underscores the potential utility of DAS181 as a new class of drug that is effective against influenza viruses with pandemic potential.
ACCESSION #
28141678

 

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