TITLE

Long-Term Effect of Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization by Streptococcus pneumoniae—and Associated Interactions with Staphylococcus aureus and Haemophilus influenzae Colonization—in HIV-Infected and HIV-Uninfected Children

AUTHOR(S)
Madhi, Shabir A.; Adrian, Peter; Kuwanda, Locadiah; Cutland, Clare; Albrich, Werner C.; Klugman, Keith P.
PUB. DATE
December 2007
SOURCE
Journal of Infectious Diseases;12/1/2007, Vol. 196 Issue 11, p1662
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in childern 5.3 years of age. In addition, human immunodeficiency virus (HIV)-infected children (n = 81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6% and 74.1%, respectively) than did HIV-uninfected children (n = 271; 50.9% and 52.0%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in HIV-infected children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in HIV-uninfected children, possibly as a result of suboptimal adaptive immunity after previous colonization in HIV-infected children.
ACCESSION #
28141665

 

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