TITLE

Profile of T Cell Immune Responses in HIV-Infected Children from Uganda

AUTHOR(S)
Ssewanyana, Isaac; Elrefaei, Mohamed; Dorsey, Grant; Ruel, Theodore; Jones, Norman G.; Gasasira, Anne; Kamya, Moses; Nakiwala, Justine; Achan, Jane; Charlebois, Edwin; Havlir, Diane; Huyen Cao
PUB. DATE
December 2007
SOURCE
Journal of Infectious Diseases;12/1/2007, Vol. 196 Issue 11, p1667
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Human immunodeficiency virus (HIV) immunopathogenesis in children remains poorly understood. We assessed T cell immune activation in antiretroviral therapy-naive children in Uganda (n = 154). Increased CD4+ and CD8+ T cell activation strongly correlated with decreased CD4+ T cell percentage. Interestingly, no correlation between plasma HIV RNA level and T cell activation was observed after controlling for CD4+ T cell count. In addition, the presence of Gag-specific CD4+ T helper responses was associated with increased HIVspecific CD8+ T cells. Understanding the balance between immuneactivation and T cell immunity in HIV-infected children may provide further insights into the mechanisms leading to effective immune control.
ACCESSION #
28141657

 

Related Articles

  • High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort. Nakanjako, Damalie; Ssewanyana, Isaac; Mayanja-Kizza, Harriet; Kiragga, Agnes; Robert Colebunders; Manabe, Yukari C; Rose Nabatanzi; Kamya, Moses R; Cao, Huyen // BMC Infectious Diseases;2011, Vol. 11 Issue 1, p43 

    Background: Antiretroviral therapy (ART) partially corrects immune dysfunction associated with HIV infection. The levels of T-cell immune activation and exhaustion after long-term, suppressive ART and their correlation with CD4 T-cell count reconstitution among ART-treated patients in African...

  • Antiretroviral Therapy for HIV-1-Infected Children in Haiti. Erik George; Francine Noël; Bois, Gyrlande; Cassagnol, Rachelle; Estavien, Louise; de Matteis Rouzier, Patricia; Verdier, Rose I.; Johnson, Warren D.; Pape, Jean W.; Fitzgerald, Daniel W.; Wright, Peter F. // Journal of Infectious Diseases;5/15/2007, Vol. 195 Issue 10, p1411 

    Background. Data are limited about the effectiveness of pediatric antiretroviral therapy (ART) in low-income countries. Methods. We report the outcomes of consecutively treating 236 human immunodeficiency virus type 1 (HIV - 1)—infected treatment-naive children with triple ART in...

  • Modelling T4 cell count as a marker of HIV progression in the absence of any defense mechanism. Yadavalli, Venkata S. Sarma; Labeodan, Moremi Morire OreOluwapo; Udayabaskaran, Swaminathan; Forche, N. // Orion;2010, Vol. 26 Issue 2, p113 

    The T4 cell count, which is considered one of the markers of disease progression in an HIV infected individual, is modelled in this paper. The World Health Organisation has recently advocated that countries encourage HIV infected individuals to commence antiretroviral treatments once their T4...

  • HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment. Rueda, Cesar Mauricio; Velilla, Paula Andrea; Chougnet, Claire A.; Montoya, Carlos Julio; Rugeles, Maria Teresa // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Peripheral blood T-cells from untreated HIV-1-infected patients exhibit reduced immune responses, usually associated with a hyperactivated/exhausted phenotype compared to HAART treated patients. However, it is not clear whether HAART ameliorates this altered phenotype of T-cells in the...

  • HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment. Rueda, Cesar Mauricio; Velilla, Paula Andrea; Chougnet, Claire A.; Montoya, Carlos Julio; Rugeles, Maria Teresa // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Peripheral blood T-cells from untreated HIV-1-infected patients exhibit reduced immune responses, usually associated with a hyperactivated/exhausted phenotype compared to HAART treated patients. However, it is not clear whether HAART ameliorates this altered phenotype of T-cells in the...

  • CD28-Negative CD4+ and CD8+ T Cells in Antiretroviral Therapy–Naive HIV-Infected Adults Enrolled in Adult Clinical Trials Group Studies. Tassiopoulos, Katherine; Landay, Alan; Collier, Ann C.; Connick, Elizabeth; Deeks, Steven G.; Hunt, Peter; Lewis, Dorothy E.; Wilson, Cara; Bosch, Ronald // Journal of Infectious Diseases;Jun2012, Vol. 205 Issue 11, p1730 

    Background Individuals infected with human immunodeficiency virus (HIV) have higher risk than HIV-negative individuals for diseases associated with aging. T-cell senescence, characterized by expansion of cells lacking the costimulatory molecule CD28, has been hypothesized to mediate these risks....

  • Multidisciplinary, Inpatient Directly Observed Therapy for HIV-1–Infected Children and Adolescents Failing HAART: A Retrospective Study. Parsons, Genevieve N.; Siberry, George K.; Parsons, J. Kellogg; Christensen, James R.; Joyner, Mary L.; Lee, Stephanie L.; Kiefner, Carolyn M.; Hutton, Nancy // AIDS Patient Care & STDs;Apr2006, Vol. 20 Issue 4, p275 

    Children and adolescents with HIV-1 infection and elevated viral loads are at risk for disease progression. When outpatient adherence efforts fail to reduce viral loads, we have chosen to hospitalize patients for directly observed antiretroviral therapy. A retrospective chart review was...

  • Clinical Outcomes Improve with Highly Active Antiretroviral Therapy in Vertically HIV Type-1 -- Infected Children. Resino, Salvador; Resino, Rosa; Bellón, José Mª; Micheloud, Dariela; Gutiérrez, Mª Dolores Gurbindo; de José, Mª Isabel; Ramos, José Tomás; Fontelos, Pablo Martín; Ciria, Luis; Muñoz-Fernández, Mª Ángeles // Clinical Infectious Diseases;7/15/2006, Vol. 43 Issue 2, p243 

    Background. Use of antiretroviral therapy has resulted in a decrease in morbidity and mortality rates in human immunodeficiency virus type 1 (HIV-1)—infected children. Methods. We performed a retrospective study involving 427 children to determine the effectiveness of different...

  • Fixed-dose ART tablets for children with HIV show promise. Volansky, Rob // Infectious Diseases in Children;Oct2008, Vol. 21 Issue 10, p60 

    The article focuses on the treatment of children with human immunodeficiency virus (HIV) with fixed-dose antiretroviral therapy (ART) tablet. According to the physicians and caregivers in India involved in pediatric HIV/Acquired immunodeficiency syndrome (AIDS), the administration of ART tablet...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics