For IL-17 Producing Helper T Cells, Autoimmunity is in the Mix

Breindl, Anette
January 2008
BioWorld Today;1/7/2008, Vol. 19 Issue 4, p1
The article deals with two papers published in "Nature Immunology" which investigated the contribution of interleukin-17 producing cells to autoimmune disease. In the paper "Interleukin 17-producing T Helper Cells and Interleukin 17 Orchestrate Autoreactive Germinal Center Development in Autoimmune BXD2 Mice," researchers describe a new mechanism by which IL-17 does its damage when it is produced by TH17-type cells. The second paper focuses on how IL-17 production is regulated and what makes TH17 type cells go bad.


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