Diagnosis of gestational diabetes mellitus using a modified 100 g oral glucose tolerance test

Phaloprakarn, C.; Tangjitgamol, S.
January 2008
Journal of Perinatology;Jan2008, Vol. 28 Issue 1, p7
Academic Journal
Objective:To determine an optimal cutoff level of a modified 100 g oral glucose tolerance test (OGTT) with its diagnostic performance for gestational diabetes mellitus (GDM).Study Design:Obstetric records of 909 women who had undergone a 100 g OGTT were reviewed. A modified 100 g OGTT referred to a test using a summation of 1 and 2 h plasma glucose levels after 100 g glucose ingestion. The sensitivity and specificity of this summed glucose at various cutoff levels for diagnosing GDM were obtained. A receiver operating characteristic curve was then constructed to determine the optimal value for a GDM diagnosis.Result:Based on a conventional 100 g OGTT, GDM was detected in 155 women (17.1%). Using a modified 100 g OGTT, the optimal summed glucose value for GDM diagnosis was 341 mg 100 ml−1 which yielded 93.5% sensitivity and 95.2% specificity.Conclusion:The modified 100 g OGTT demonstrated high diagnostic performance for GDM, with advantages over a conventional 100 g OGTT in terms of less time consuming, lower cost and fewer number of venipuncture.Journal of Perinatology (2008) 28, 7–11; doi:10.1038/sj.jp.7211851; published online 25 October 2007


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