TITLE

Renoprotection with vitamin D: Specific for diabetic nephropathy?

AUTHOR(S)
Klaus, G.
PUB. DATE
January 2008
SOURCE
Kidney International;Jan2008, Vol. 73 Issue 2, p141
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR–/– mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,25(OH)2D3 on inhibition of the renin–angiotensin system (RAS) in vitro. The authors conclude that the higher activation of the intrarenal RAS is the key factor to induce more severe diabetic nephropathy in VDR–/– mice.Kidney International (2008) 73, 141–143; doi:10.1038/sj.ki.5002693
ACCESSION #
28048631

 

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