Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in London

Roche, Anita; Heath, Paul I.; Sharland, Mike; Strachan, David; Breathnach, Aodhan; Haigh, John; Young, Yvonne
December 2007
Archives of Disease in Childhood;Dec2007, Vol. 92 Issue 12, p1073
Academic Journal
Objective: To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London. Design and subjects: Cross-sectional survey of attendees at a sample of registered child day care centres (CDCCs) in a London borough. Setting: Urban setting with a socially and culturally diverse population. Methods and outcomes: 19 CDCCs (13% of total) participated between March and November 2003. A single NP swab was required from each child, and parents completed a questionnaire about their child's health and attendance at day care. WHO methodology for pneumococcal carriage studies was followed. Results: 30% of parents consented. 234 swabs were collected from children aged 6 months to 5 years. 53% were boys and 81% were white. 120 children (51%, 95% CI 45% to 58%) carried pneumococci in their nasopharynx. None of the isolates were resistant to penicillin (upper CL 3%). 21 isolates were resistant to erythromycin (17.5%, 95% CI 11% to 25.5%). 68 isolates (57%) were serotypes included in the 7-valent conjugate vaccine. Non-white children had a lower prevalence of carriage (27% vs 58%). Conclusion: The prevalence of pneumococcal NP carriage was high. The penicillin resistance rate is lower than in many other countries and may reflect a decrease in community antibiotic prescribing in the UK. Monitoring circulating serotypes is important in the context of recent changes to the vaccination policy. Further study is required to explore the association with ethnicity and risk factors for antibiotic resistance.


Related Articles

  • Nasopharyngeal Bacterial Interactions in Children. Almudevar, Anthony // Emerging Infectious Diseases;Feb2014, Vol. 20 Issue 2, p324 

    A response by Anthony Almudevar to a letter to the editor about his article "Nasopharyngeal Bacterial Interactions in Children" by Q. Xu et al. in a 2012 issue is presented.

  • Nasopharyngeal Bacterial Interactions in Children. Motoi Suzuki; Dhoubhadel, Bhim Gopal; Yoshida, Lay Myint; Koya Ariyoshi // Emerging Infectious Diseases;Feb2014, Vol. 20 Issue 2, p323 

    A letter to the editor is presented in response to the article "Nasopharyngeal Bacterial Interactions in Children" by Q. Xu et al. in a 2012 issue.

  • Hemorrhage and shock associated with invasive Pneumococcal infection in healthy infants and...  // MMWR: Morbidity & Mortality Weekly Report;1/6/1995, Vol. 43 Issue 51/52, p849 

    Investigates the death of four children in New Mexico from the period between December 1993 to May 1994. Description of the disease; Infection with Streptococcus pneumoniae; Potential transmission in the child care center; Prevention measures.

  • Editorial Response: Multidrug-Resistance Stretoccus pneumoniae: An Opportunity to Further... Leach, Amanda Jane // Clinical Infectious Diseases;11/1/1999, Vol. 29 Issue 5, p1265 

    Editorial. Responds to a report by Craig et al. about an outbreak of cases of meningitis due to serotype multiple drug-nonsusceptible Streptococcus pneumoniae (MDRSP) in a Tennessee child care center. Similarity in carriage rates of MDRSP at the index center and comparator child care centers;...

  • Characteristics of Streptococcus pneumoniae and Atypical Bacterial Infections in Children 2--5 Years of Age with Community-Acquired Pneumonia. Esposito, Susanna; Bosis, Samantha; Cavagna, Roberta; Faelli, Nadia; Begliatti, Enrica; Marchisio, Paola; Blasi, Francesco; Bianchi, Ciro; Principi, Nicola // Clinical Infectious Diseases;12/1/2002, Vol. 35 Issue 11, p1345 

    The characteristics of community-acquired pneumonia associated with Streptococcus pneumoniae infection were compared with those associated with atypical bacterial infection and with mixed S. pneumoniae-atypical bacterial infection in 196 children aged 2-5 years. S. pneumoniae infections were...

  • Antimicrobial Use and Colonization with Erythromycin-Resistant Streptococcus pneumoniae in... Syrogiannopoulos, George A.; Grivea, Ioanna N.; Davies, Todd A.; Katopodis, George D.; Appelbaum, Peter C.; Beratis, Nicholas G. // Clinical Infectious Diseases;10/1/2000, Vol. 31 Issue 4, p887 

    Evaluates nasopharyngeal colonization with erythromycin-resistant Streptococcus pneumoniae during the first two years of life in central and southern Greece. Relationship between carriage of erythromycin-resistant pneumococci and use of macrolides or beta-lactams in the previous three months;...

  • Marked Difference in Pneumococcal Carriage and Resistance Patterns between Day Car Centers... Givon-Lavi, Noga; Dagan, Ron; Fraser, Drora; Yagupsky, Pablo; Porat, Nurith // Clinical Infectious Diseases;11/1/1999, Vol. 29 Issue 5, p1274 

    Studies carriage rates of Streptococcus pneumoniae and their antibiotic resistance, capsular types and genetic patterns among children aged 12-35 months attending day care centers in the same city. Nasopharyngeal cultures obtained from children; Significant differences in each of the studied...

  • Bacterial contamination in child care centers and diaper type.  // Child Health Alert;May95, Vol. 13, p1 

    Comments on the results of a study conducted by researchers from Vanderbilt University in Nashville, Tenn., who sought to determine the influence of disposable and cloth diapers on fecal contamination in infants and toddlers in American child care centers. High rate of infectious diseases in...

  • Prevalence, Determinants, and Molecular Epidemiology of Streptococcus pneumoniae Isolates Colonizing the Nasopharynx of Healthy Children in Rome. Petrosillo, N.; Pantosti, A.; Bordi, E.; Spanó, A.; Del Grosso, M.; Tallarida, B.; Ippolito, G. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2002, Vol. 21 Issue 3, p181 

    The aim of this study was to determine the factors favouring Streptococcus pneumoniae nasopharyngeal colonization of healthy children attending daycare centres and to describe the circulation of penicillin-nonsusceptible strains using molecular techniques. A single nasopharyngeal swab was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics