Valproate was more effective than lamotrigine and better tolerated than topiramate in generalized or unclassified epilepsy

November 2007
ACP Journal Club;Nov/Dec2007, Vol. 147 Issue 3, p75
Academic Journal
The article presents a research study to understand the efficacy of anticonvulsant valproate (VAL) than anticonvulsants lamotrigine (LTG) and topiramate (TPM) for generalized and unclassifiable epilepsy. It mentions the setting and subject of the study, along with its outcomes and conclusion. Results show VAL to be more effective than TPM but it did not differ from LTG. It concludes the efficacy of VAL over LTG and better tolerance than TPM in generalized or unclassified epilepsy.


Related Articles

  • The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies. Nicolson A; Appleton R E; Chadwick D W; Smith D F // Journal of Neurology, Neurosurgery & Psychiatry;Jan2004, Vol. 75 Issue 1, p75 

    OBJECTIVE: To examine a large population with idiopathic generalised epilepsy (IGE), and estimate the overall remission rates for the IGEs and subsyndromes in a clinic based sample. Remission rates on valproate, lamotrigine, topiramate, and combinations of these antiepileptic drugs were...

  • Lamotrigine.  // Reactions Weekly;11/24/2007, Issue 1179, p22 

    The article describes the case of a 37-year old woman who developed blood dyscrasias and rash while receiving lamotrigine. Results from laboratory investigations were obtained. The patient reported muscle aches during treatment with lamotrigine and valproate semisodium. Her leucocyte count...

  • Reinvestigation and Reduction of Polytherapy in Children With Chronic Seizures. Chu-Chin Chen; Pao-Chin Chiu; Mei-Tsen Chen // Journal of Child Neurology;Jan2007, Vol. 22 Issue 1, p15 

    From October 2001 to October 2003, the authors reviewed all patients with chronic seizures taking antiepileptic drugs for more than 2 years with follow-up at the pediatric neurological clinic. They identified 31 patients who were using 3 or more drugs. Twenty-nine patients agreed to undergo a...

  • Influence of Enzyme-Inducing Antiepileptic Drugs on Trough Level of Imatinib in Glioblastoma Patients. Pursche, Stefan; Schleyer, Eberhard; von Bonin, Malte; Ehninger, Gerhard; Said, Samir Mustafa; Prondzinsky, Roland; Illmer, Thomas; Yanfeng Wang; Hosius, Christian; Nikolova, Zariana; Bornhäuser, Martin; Dresemann, Gregor // Current Clinical Pharmacology;Sep2008, Vol. 3 Issue 3, p198 

    Background: Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme (GBM). CYP3A4 enzyme-inducing antiepileptic drugs (EIAEDs) like carbamazepine, phenytoin, and oxcarbazepine -- as well as non-EIAEDs like valproic...

  • Epilepsy in pregnancy: Pharmacodynamics and pharmacokinetics. Doyle, Lisa; Geraghty, Sadie; Folan, Margaret // British Journal of Midwifery;Dec2016, Vol. 24 Issue 12, p830 

    After headache, epilepsy is the second most common neurological disorder encountered in pregnancy. Epilepsy is one of the most common chronic neurological conditions in the world, with an estimated 50 million people affected worldwide. The majority of pregnant women with epilepsy have an...

  • Mono- and combination drug therapies in hospitalized patients with bipolar depression. Data from the European drug surveillance program AMSP. Haeberle, Anne; Greil, Waldemar; Russmann, Stefan; Grohmann, Renate // BMC Psychiatry;2012, Vol. 12 Issue 1, p153 

    Background: For the pharmacological treatment of bipolar depression several guidelines exist. It is largely unknown, to what extent the prescriptions in daily clinical routine correspond to these evidence based recommendations and which combinations of psychotropic drugs are frequently used....

  • Lamotrigine.  // Reactions Weekly;3/22/2008, Issue 1194/1195, p22 

    The article describes a case of lamotrigine-induced anticonvulsant hypersensitivity syndrome. It references a study by E. Ozaydin and colleagues, published in a 2007 issue of "Allergy." A girl, with a history of epilepsy, developed fever and rash after receiving lamotrigine for seizures. Her...

  • Lamotrigine/valproic acid.  // Reactions Weekly;Dec2015, Vol. 1580 Issue 1, p225 

    The article describes the case of a 35-year-old female patient who developed Stevens-Johnson syndrome (SJS) after being treated for seizures with lamotrigine and valproic acid.

  • Topiramate.  // Reactions Weekly;5/14/2005, Issue 1051, p17 

    Discusses research being done on the association of erectile dysfunction with topiramate. Reference to a study by M. Holtkamp and colleagues published in the January 2005 issue of "Epilepsia"; Effect of topiramante on partial epilepsy; Reasons behind the occurrence of erectile dysfunction.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics