TITLE

Mixed-mode stationary phases as a complementary selectivity concept in liquid chromatography—tandem mass spectrometry-based bioanalytical assays

AUTHOR(S)
Bicker, Wolfgang; Lämmerhofer, Michael; Lindner, Wolfgang
PUB. DATE
January 2008
SOURCE
Analytical & Bioanalytical Chemistry;Jan2008, Vol. 390 Issue 1, p263
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the potential of mixed-mode stationary phases to serve as an alternative separation concept for bioanalytical investigations of polar analytes when reverse-phase (RP) chromatography experiences retention and selectivity problem. Mixed-mode phases combining orthogonal separation principles provide much more optimisation potential than classical RP chromatography. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed for the simultaneous analysis of EtG and EtS as well as ethyl phosphate (EtP) in human urine.
ACCESSION #
28000642

 

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