TITLE

Prevalence of Monoclonal Gammopathy of Undetermined Significance Among Men in Ghana

AUTHOR(S)
Landgren, Ola; Katzmann, Jerry A.; Hsing, Ann W.; Pfeiffer, Ruth M.; Kyle, Robert A.; Yeboah, Edward D.; Biritwum, Richard B.; Tetfey, Yao; Adjei, Andrew A.; Larson, Dirk R.; Dispenzieri, Angela; Melton III, L. Joseph; Goldin, Lynn R.; Mcmaster, Mary L.; Caporaso, Neil E.; Rajkumar, S. Vincent
PUB. DATE
December 2007
SOURCE
Mayo Clinic Proceedings;Dec2007, Vol. 82 Issue 12, p1468
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: To determine the prevalence of monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma (MM), in Ghanaian men vs white men and to test for evidence to support an underlying race-related predisposition of the 2-fold higher prevalence of MGUS in African Americans vs whites. PARTICIPANTS AND METHODS: Between September 1, 2004, and September 30, 2006, 917 men (50-74 years) underwent in-person interviews and physical examinations. Serum samples from all participants were analyzed by electrophoresis performed on agarose gel; any serum sample with a discrete or localized band was subjected to immunofixation. Age-adjusted and standardized (to the 2000 world population) prevalence estimates of MGUS and 95% confidence intervals (Cls) were computed in the Ghanaian men and compared with MGUS prevalence in 7996 white men from Minnesota. Associations between selected characteristics and MGUS prevalence were assessed by the Fisher exact test and logistic regression models. RESULTS: Of the 917 study participants, 54 were found to have MGUS, yielding an age-adjusted prevalence of 5.84(95% Cl, 4.27-7.40) per 100 persons. No significant variation was found by age group, ethnicity, education status, or prior infectious diseases. The concentration of monoclonal immunoglobulin was undetectable in 41 (76%) of the 54 MGUS cases, less than 1 g/dL in 10 patients (19%), and 1 g/dL or more in only 3 patients (6%). Compared with white men, the age-adjusted prevalence of MGUS was 1.97-fold (95% Cl, 1.94-2.00) higher in Ghanaian men. CONCLUSION: The prevalence of MGUS in Ghanaian men was twice that in white men, supporting the hypothesis that race-related genetic susceptibility could explain the higher rates of MGUS in black populations. An improved understanding of MGUS and MM pathophysiology would facilitate the development of strategies to prevent progression of MGUS to MM.
ACCESSION #
27828549

 

Related Articles

  • Prevalence of Monoclonal Gammopathy of Undetermined Significance: Study of 52,802 Persons in Nagasaki City, Japan. Iwanaca, Masako; Tagawa, Masuko; Tsukasaki, Kunihiro; Kamihira, Shimera; Tomonaga, Masao // Mayo Clinic Proceedings;Dec2007, Vol. 82 Issue 12, p1474 

    OBJECTIVE: To assess the prevalence of monoclonal gammopathy of undetermined significance (MGUS) In a large Japanese population. PARTICIPANTS AND METHODS: From October 1, 1988, to March 31, 2004, a total of 52,802 (of 71,675) Japanese survivors of the atomic bomb explosion in Nagasaki City,...

  • Protein Electrophoresis and Immunofixation for the Diagnosis of Monoclonal Gammopathies. Rajkumar, S. Vincent; Kyle, Robert A. // JAMA: Journal of the American Medical Association;11/26/2014, Vol. 312 Issue 20, p2160 

    The article reviews the application of urine protein electrophoresis and serum immunofixation in the case of a woman in her 70s who was diagnosed with monoclonal gammopathy of undetermined significance (MGUS). Data provided shows the patient's laboratory values and describes the characteristics...

  • Comparison of Hevyliteâ„¢ IgA and IgG assay with conventional techniques for the diagnosis and follow-up of plasma cell dyscrasia. Di Noto, Giuseppe; Maffina, Francesca; Martellosio, Giovanni; Radeghieri, Annalisa; Luigi, Caimi; Ricotta, Doris; Paolini, Lucia // Annals of Clinical Biochemistry;May2015, Vol. 52 Issue 3, p337 

    Background:Heavy/light chain assay allows the characterization and quantification of immunoglobulin light chains bound to heavy chains for each Ig'k and Ig' immunoglobulin class, discriminating between the involved/uninvolved isotypes in plasma cell dyscrasia. The Ig'k/Ig' ratio (heavy/light...

  • Serum Immunoglobulin Free Light Chains in Patients with Monoclonal Gammapathies. Lubimova, N.; Turko, T.; Votyakova, O.; Kushlinskii, N. // Bulletin of Experimental Biology & Medicine;Jun2012, Vol. 153 Issue 2, p249 

    Serum concentrations of κ- and λ-free light chains and their ratios were compared in 126 patients with monoclonal gammapathies (age 23-80 years) and 60 normal subjects (25-82 years). The main group included patients with intact immunoglobulin multiple myeloma, Bence Jones multiple myeloma,...

  • Bone marrow uptake of 99mTc-MIBI in patients with multiple myeloma. Fonti, R.; Del Vecchio, S.; Zannetti, A.; De Renzo, A.; Di Gennaro, F.; Catalano, L.; Califano, C.; Pace, L.; Rotoli, B.; Salvatore, M. // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 2, p214 

    Abstract. In a previous study, we showed the ability of technetium-99m methoxyisobutylisonitrile ([sup 99m]Tc-MIBI) scan to identify active disease in patients with multiple myeloma (Eur J Nucl Med 1998; 25: 714-720). In particular, a semiquantitative score of the extension and intensity of bone...

  • Online CME Quiz Questions. Multiple Myeloma Precursor Disease.  // JAMA: Journal of the American Medical Association;12/1/2010, Vol. 304 Issue 21, p2421 

    A online continuing medical education (CME) quiz about multiple myeloma precursor disease is presented.

  • Urinary proteins in multiple myeloma: correlation with clinical parameters and diagnostic implications. Corso, A.; Zappasodi, P.; Pascutto, C.; Bosoni, T.; Mangiacavalli, S.; Lorenzi, A.; Rusconi, C.; Lazzarino, M. // Annals of Hematology;Aug2003, Vol. 82 Issue 8, p487 

    Renal failure is one of the worst complications occurring in multiple myeloma (MM) patients. It does not affect survival if reverted by a prompt chemotherapy before the damage becomes irreversible; therefore, the early diagnosis of renal dysfunction is crucial. High and low molecular weight...

  • Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy. Fonseca, R; Oken, M M; Harrington, D; Bailey, R J; Van Wier, S A; Henderson, K J; Kay, N E; Van Ness, B; Greipp, P R; Dewald, G W // Leukemia (08876924);Jun2001, Vol. 15 Issue 6, p981 

    Deletions of the long arm of chromosome 13 (13q-) are observed in patients with multiple myeloma (MM), are rarely observed in the monoclonal gammopathy of undetermined sig-nificance (MGUS) and have been associated with a worsened prognosis in MM. However, no minimally deleted region in the13q...

  • 4. From MGUS to symptomatic MM.  // Hematology Journal;2003 Supplement, Vol. 4 Issue 1, pS31 

    The Hematology Journal (2003) 4, S31-S34. doi:10.1038/sj.thj.6200271

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics