T Helper 1/Helper 2 Cell Immunity in Preeclamptic Twin Pregnancy

Sujuki, Shunji; Ouchi, Nozomi
December 2007
Journal of Nippon Medical School;2007, Vol. 74 Issue 6, p434
Academic Journal
Preeclampsia has been classified into two types on the basis of the T helper (Th)1/Th2 balanced: Th1-predominant type and Th2 predominant type. In this study, we examined the Th1/Th2 ration in peripheral Th cells in 11 patients with preeclamptic twin pregnancies, 11 normal (nonpreeclamptic) twin pregnancies, 11 preeclamptic singleton pregnancies, and 11 normal singleton pregnancies. The average Th1/Th2 ration in the patients with preeclamptic twin pregnancy was 8.3 ± 3.4 (mean ± SD), which was similar to those in patients with normal singleton and twin pregnancies and significant lower than that in patients with preeclamptic singleton pregnancies (p = 0.003). The present results suggest that the mechanisms of preeclampsia differ between singleton and twin pregnancies.


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