TITLE

Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function

AUTHOR(S)
Goschnick, Matt W.; Jackson, Denise E.
PUB. DATE
December 2007
SOURCE
Mini Reviews in Medicinal Chemistry;Dec2007, Vol. 7 Issue 12, p1248
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the �outside-in� signalling properties of the major platelet integrin, integrin aIIb�3 and thrombus stability in vivo.
ACCESSION #
27659775

 

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