Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function

Goschnick, Matt W.; Jackson, Denise E.
December 2007
Mini Reviews in Medicinal Chemistry;Dec2007, Vol. 7 Issue 12, p1248
Academic Journal
There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the �outside-in� signalling properties of the major platelet integrin, integrin aIIb�3 and thrombus stability in vivo.


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