Effect of parental smoking on cotinine levels in newborns

Joseph, D. V.; Jackson, J. A.; Westaway, J.; Taub, N. A.; Petersen, S. A.; Wailoo, M. P.
November 2007
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2007, Vol. 92 Issue 6, pF484
Academic Journal
Background: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful. Aim: To assess cotinine levels in infants of smoking parents. Method: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development. Results: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% Cl 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors. Conclusion: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.


Related Articles

  • Review finds that bed sharing increases risk of sudden infant death syndrome. Shaefer, Sarah J. M. // Evidence Based Nursing;Oct2012, Vol. 15 Issue 4, p115 

    The author comments on a study "Bed sharing and the risk of sudden infant death syndrome (SIDS): can we resolve the debate?" by M.M. Vennemann and colleagues. The study revealed that bed sharing increases the risk of SIDS. She opines that the study is comprehensive, provides international data,...

  • Bed sharing increases SIDS risk by up to five times.  // Community Practitioner;Jul2013, Vol. 86 Issue 7, p7 

    The article discusses the study led by Professor Bob Carpenter of the London School of Hygiene and Tropical Medicine which found an increased risk of sudden infant death syndrome (SIDS) among young babies who bed share with parents.

  • NICE updates guidance on co-sleeping.  // Community Practitioner;Feb2015, Vol. 88 Issue 2, p8 

    The article reports on the move of the National Institute for Health and Care Excellence (NICE) to update its clinical guidance on co-sleeping with infants due to the association between co-sleeping and suddent infant death syndrome (SIDS).

  • Sudden unexpected death in infancy (SUDI) in the early neonatal period: the role of bed-sharing. Hoffend, Charlotte; Sperhake, Jan-Peter // Forensic Science, Medicine & Pathology;Jun2014, Vol. 10 Issue 2, p157 

    The incidence of sudden infant death syndrome (SIDS) has declined substantially, but the proportion of sudden unexpected death in infancy (SUDI) in neonates, <7 days old, has increased among all SUDI cases in the first year of life. The aim of this study was to analyze circumstances and common...

  • PÄ“pi-pods contribute to safe sleeping for babies.  // Kai Tiaki Nursing New Zealand;Mar2014, Vol. 20 Issue 2, p9 

    No abstract available.

  • Clinical digest. Bed sharing with infants is risky, even when the parents are non-smokers.  // Nursing Standard;6/26/2013, Vol. 27 Issue 43, p14 

    The article focuses on a study into a possible correlation between sudden infant death syndrome (SIDS) and parents sharing their bed with infants. It states bed sharing was reported in 22.2 percent of SIDS cases and 9.6 percent in a control study and speculates 88 percent of SIDS deaths while...

  • Highlights from this issue. Beattie, R. Mark // Archives of Disease in Childhood -- Education & Practice Edition;Jul2015, pi 

    An introduction is presented which discusses various reports within the issue on topics including the presentation of numerical data, the link between bed sharing and the risk of sudden infant death in infants, and the prevalence of severe childhood obesity in England.

  • Ondine's Curse and Sudden Infant Death Syndrome: Teetering on the Brink. Faigel, Harris C. // Clinical Pediatrics;Jul1974, Vol. 13 Issue 7, p567 

    Provides information about Ondine's curse and sudden infant death syndrome. Difficulties in diagnosing SIDS; Prevalence of bradypnea and apnea among premature infants; Occurrence of respiratory distress among newborns who die of SIDS.

  • A Startling Case of Neonatal Hyperekplexia Responsive to Levetiracetam: A New Alternative in Management? Hussain, Shanawaz; Prasad, Manish; Rittey, Chris; Desurkar, Archanna // Journal of Child Neurology;Nov2013, Vol. 28 Issue 11, p1513 

    The authors report a case of hyperekplexia presenting in the neonatal period resistant to clonazepam that responded subsequently to levetiracetam. Hyperekplexia is often misdiagnosed as epilepsy and can be difficult to manage with a particular concern over neonatal apnea and an increased risk of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics