TITLE

Hepatitis-C Patients Have Reduced Growth Hormone (GH) Secretion Which Improves During Long-Term Therapy With Pegylated Interferon-α

AUTHOR(S)
Plöckinger, Ursula; Krüger, Denny; Bergk, Alexandra; Weich, Viola; Wiedenmann, Bertram; Berg, Thomas
PUB. DATE
December 2007
SOURCE
American Journal of Gastroenterology;Dec2007, Vol. 102 Issue 12, p2724
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: In vitro and in vivo data indicate multiple, but contradictory effects of interferon on pituitary hormone secretion. We therefore investigated prospectively basal and stimulated pituitary hormone secretion in 21 patients with chronic hepatitis C virus (HCV) infection before and during antiviral therapy. METHODS: Twenty-one patients received pegylated interferon-α plus either ribavirin or levovirin. Baseline and stimulated growth hormone (GH), cortisol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and thyroid-stimulating hormone (TSH) responses were measured using standard pituitary function tests, before therapy in all and during therapy in 17 out of the 21 patients. RESULTS: Before therapy 17 patients (81%) had severe GH insufficiency and 9 of these had low insulin-like growth factor-1 (IGF-1) concentrations. Basal and stimulated GH concentrations increased significantly during therapy, reducing the number of patients with severe GH insufficiency to four, but IGF-1 remained low. Basal PRL and TSH concentrations were normal before and during therapy, while thyroid-releasing hormone (TRH)-stimulated concentrations increased significantly during therapy. The adrenocorticotropic hormone (ACTH)/cortisol axis, basal and stimulated gonadotropin, and testosterone concentrations were normal throughout. Neither the HCV RNA level nor transaminases correlated with hormone concentrations before or during therapy. CONCLUSIONS: GH insufficiency is common in patients with chronic HCV infection. While GH secretion improves during antiviral therapy, IGF-1 remains low, indicating persistent GH resistance of hepatocytes. Whether improvement in GH secretion during treatment is due to a direct drug effect or related to the suppression of viral load could not be differentiated, as most patients demonstrated a positive virologic response.
ACCESSION #
27609322

 

Related Articles

  • Response-Guided Therapy for Chronic Hepatitis C Virus Infection in Patients Coinfected with HIV: A Pilot Trial. Van den Eynde, Eva; Crespo, Manuel; Esteban, Juan I.; Jardi, Rosend; Ribera, Esteban; Carbonell, Judit; Rodríguez-Frias, Francisco; Falco, Vicenç; Curran, Adria; Imaz, Arkaitz; del Saz, Sara Villar; Ocaña, Inma; Esteban, Rafael; Pahissa, Albert // Clinical Infectious Diseases;4/15/2009, Vol. 48 Issue 8, p1152 

    Background. To study the feasibility of a response-guided therapy for chronic hepatitis C virus (HCV) infection in patients coinfected with human immunodeficiency virus (HIV) in a tertiary care hospital. Methods. Treatment duration was individualized on the basis of week 4 and week 12 virologic...

  • Leucocyte Interferon-alpha for Patients with Chronic Hepatitis C Intolerant to Other alpha-Interferons. Tripi, Silvio; Soresi, Maurizio; Gaetano, Giuseppa Di; Carroccio, Antonio; Giannitrapani, Lydia; Vuturo, Onofrio; Giovanni, Gaetana Di; Montalto, Giuseppe // BioDrugs;2003, Vol. 17 Issue 3, p201 

    Background: Alpha-interferon (α-IFN) is the treatment of choice for chronic hepatitis C but most patients experience adverse effects which sometimes lead to the suspension of therapy. Recently, higher doses of α-IFN or prolonged therapy have increased the number of cases of intolerance....

  • Early Changes in Hepatitis C Virus (HCV) Levels in Response to Peginterferon and Ribavirin Treatment in Patients with Chronic HCV Genotype 1 Infection. Hoofnagle, Jay H.; Wahed, Abdus S.; Brown Jr., Robert S.; Howell, Charles D.; Belle, Steven H. // Journal of Infectious Diseases;4/15/2009, Vol. 199 Issue 8, p1112 

    Early changes in hepatitis C virus (HCV) RNA levels were assessed in a large cohort of African American and white patients with chronic hepatitis C due to HCV genotype 1 who underwent therapy with peginterferon alfa-2a and ribavirin in the Study of Viral Resistance to Antiviral Therapy of...

  • When Interferon Interferes. Ajamian, Paul C. // Review of Optometry;4/15/2012, Vol. 149 Issue 4, p62 

    The article provides questions and answers related to interferon interferes therapy including whether interferon interferes therapy causes problem in patient with hepatitis C and how development of retinopathy could be reduced in hepatitis C patients.

  • Peginterferon-α-2b: Psoriasis: case report.  // Reactions Weekly;Nov2013, Issue 1477, p29 

    The article presents a case study of a man who developed psoriasis while being treated for acute hepatitis C with peginterferon.

  • Pegylated Interferon-Induced Sarcoidosis Presenting With Anterior Uveitis in a Patient with Chronic Hepatitis C - Case Report. KAMAL, ADINA M.; MITRU?, P.; KAMAL, C. K.; ALEXANDRU, D. O.; TICA, A. // Current Health Sciences Journal;2015, Vol. 41 Issue 4, p379 

    Sarcoidosis is a chronic inflammatory systemic disorder of unknown etiology. It is known to be triggered by an autoimmune process, and is currently recognized as a rare adverse event to interferon therapy for Hepatitis C Virus Infection. Clinical presentation of interferon-triggered sarcoidosis...

  • Treatment of Naïve Patients with Chronic Hepatitis C Genotypes 2 and 3 with Pegylated Interferon Alpha and Ribavirin in a Real World Setting: Relevance for the New Era of DAA. Heidrich, Benjamin; Wiegand, Steffen B.; Buggisch, Peter; Hinrichsen, Holger; Link, Ralph; Möller, Bernd; Böker, Klaus H. W.; Teuber, Gerlinde; Klinker, Hartwig; Zehnter, Elmar; Naumann, Uwe; Busch, Heiner W.; Maasoumy, Benjamin; Baum, Undine; Hardtke, Svenja; Manns, Michael P.; Wedemeyer, Heiner; Petersen, Jörg; Cornberg, Markus // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Evidence based clinical guidelines are implemented to treat patients efficiently that include efficacy, tolerability but also health economic considerations. This is of particular relevance to the new direct acting antiviral agents that have revolutionized treatment of chronic hepatitis C. For...

  • Homicidal Ideation Causally Related to Therapeutic Medications. Marks, Donald H.; Breggin, Peter R.; Braslow, Derek // Ethical Human Psychology & Psychiatry;Fall2008, Vol. 10 Issue 3, p134 

    Five patients with hepatitis C (HCV), three of whom were treated with peginterferon alfa-2 (IFN) and two who were not treated with IFN, developed homicidal ideation (HI) during a 4-year period. Following accepted rules for determining causation, there appeared to be a causal relatedness between...

  • Serum alpha-fetoprotein levels during and after interferon therapy and the development of hepatocellular carcinoma in patients with chronic hepatitis C. Tamura, Yasushi; Yamagiwa, Satoshi; Aoki, Yohei; Kurita, So; Suda, Takeshi; Ohkoshi, Shogo; Nomoto, Minoru; Aoyagi, Yutaka; Niigata Liver Disease Study Group // Digestive Diseases & Sciences;Nov2009, Vol. 54 Issue 11, p2530 

    The association between serum alpha-fetoprotein (AFP) levels during and after interferon (IFN) therapy and the development of hepatocellular carcinoma (HCC) was evaluated in patients with chronic hepatitis C (CHC). A total of 263 patients treated by IFN with or without ribavirin were enrolled in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics