TITLE

IL23R R381Q and ATG16L1 T300A Are Strongly Associated With Crohn's Disease in a Study of New Zealand Caucasians With Inflammatory Bowel Disease

AUTHOR(S)
Roberts, Rebecca L.; Gearry, Richard B.; Hollis-Moffatt, Jade E.; Miller, Allison L.; Reid, Julia; Abkevich, Victor; Timms, Kirsten M.; Gutin, Alexander; Lanchbury, Jerry S.; Merriman, Tony R.; Barclay, Murray L.; Kennedy, Martin A.
PUB. DATE
December 2007
SOURCE
American Journal of Gastroenterology;Dec2007, Vol. 102 Issue 12, p2754
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: Recently, separate genome-wide association analyses have identified nonsynonymous SNPs in IL23R and ATG16L1 ( rs11209026; c1142G>A, R381Q, and rs2241880; c1338A>G, T300A, respectively) as strong candidate susceptibility factors for Crohn's disease (CD) in whites. The aim of our study was to test whether these SNPs are associated with CD in a population-based cohort of New Zealand Caucasian inflammatory bowel disease (IBD) patients. METHODS: Allele frequencies of rs11209026 and rs2241880 were determined in 496 CD patients, 466 ulcerative colitis (UC) patients, and 591 controls. Distribution of the relevant alleles was compared between controls and IBD patients. rs11209026 and rs2241880 genotype distributions were examined both within IBD clinical subphenotypes and CARD15 genotypes. RESULTS: rs11209026 and rs2241880 were both associated with CD ( P value rs11209026= 0.0026, OR 0.54, 95% CI 0.36–0.81; P value rs2241880= 0.0001, OR 1.41, 95% CI 1.18–1.67). In addition, there was evidence for association of rs11209026 with UC ( P value = 0.037, OR 0.66, 95% CI 0.45–0.98). No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes. IL23R was associated with CD and UC only in the absence of CARD15 mutations, whereas ATG16L1 was associated with CD in the presence and absence of CARD15 mutations. CONCLUSIONS: We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population. We also provide further evidence for association of rs11209026 with UC and a report of an additive effect between IL23R and CARD15 genotypes in CD.
ACCESSION #
27609305

 

Related Articles

  • Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. Yamazaki, K.; Takazoe, M.; Tanaka, T.; Kazumori, T.; Nakamura, Y. // Journal of Human Genetics;2002, Vol. 47 Issue 9, p469 

    Chronic inflammatory bowel diseases (IBDs), specifically Crohn's disease (CD) and ulcerative colitis (UC), have increased significantly in western countries and Japan over the last decade, but very little is known about their pathogenesis. A candidate-gene approach recently identified...

  • Ulcerative colitis and Crohn's disease--susceptibility genes and clinical patterns. Jewell, Derek P. // Journal of Gastroenterology;1998, Vol. 33 Issue 3, p458 

    Reviews an article on susceptibility genes and clinical patterns of ulcerative colitis and Crohn's disease. Clinical observations suggesting genetic basis for the diseases; Details of the mode of inheritance of a complex disease; Discussion of genome searching in inflammatory bowel disease.

  • Inflammatory Bowel Disease: Its Present and Its Future. Kirsner, Joseph B. // American Journal of Gastroenterology;Nov1989, Vol. 84 Issue 11, p1358 

    Discusses the developments in the treatment of inflammatory bowel disease (IBD) as of 2005. Experiment done to determine the treatment for IBD; Pathogenesis of IBD; Microbial cause of IBD.

  • Polymorphism of the IRGM Gene Might Predispose to Fistulizing Behavior in Crohn's Disease. Latiano, A.; Palmieri, O.; Cucchiara, S.; Castro, M.; D'Incà, R.; Guariso, G.; Dallapiccola, B.; Valvano, M. R.; Latiano, T.; Andriulli, A.; Annese, V. // American Journal of Gastroenterology;Jan2009, Vol. 104 Issue 1, p110 

    OBJECTIVES: Recently, genome-wide association analyses have identified single nucleotide polymorphisms in the IRGM gene (rs1000113 and rs4958847) as strong candidate susceptibility factors for Crohn's disease (CD). The aim of our study was to test whether these variants are associated with...

  • Natalizumab.  // Reactions Weekly;6/25/2005, Issue 1057, p14 

    Discusses research being done on progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. Reference to a study by G. Van Assche et al published in the 2005 issue of the "New England Journal of Medicine"; Findings of the study.

  • CXCR3 Axis: Role in Inflammatory Bowel Disease and its Therapeutic Implication. Singh, Udai P.; Venkataraman, Chandrasekar; Singh, Rajesh; Lillard Jr., James W. // Endocrine, Metabolic & Immune Disorders - Drug Targets;Jun2007, Vol. 7 Issue 2, p111 

    There is a great need for new intervention and prevention strategies against Crohn's disease (CD), a chronic, relapsing tissue-destructive inflammatory bowel disease (IBD). Estimates indicate more than 1 million cases of IBD in the United States occur annually, with 50% involving CD. The...

  • Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases. Klein, W; Tromm, A; Griga, T; Fricke, H; Folwaczny, C; Hocke, M; Eitner, K; Marx, M; Duerig, N; Epplen, J T // Genes & Immunity;Aug2001, Vol. 2 Issue 5, p287 

    Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine production from Th I lymphocytes. Functionally relevant polymorphisms have been described in the interleukin-4 and the...

  • Lamina Propria and Circulating Interleukin-8 in Newly and Previously Diagnosed Pediatric Inflammatory Bowel Disease Patients. Krishna Reddy; Eduardo Ruchelli // Digestive Diseases & Sciences;Feb2007, Vol. 52 Issue 2, p365 

    Abstract??Dysregulation of interleukin-8 (IL-8) production has been proposed to contribute to intestinal inflammation in inflammatory bowel disease (IBD) patients. Previous studies, which evaluate adult patients with long-standing or steroid-modulated disease, have reported conflicting results...

  • Mucosal cytokine network in inflammatory bowel disease. Andoh, Akira; Yagi, Yuhki; Shioya, Makoto; Nishida, Atsushi; Tsujikawa, Tomoyuki; Fujiyama, Yoshihide; Costa, Francesco; Das, Kiron M. // World Journal of Gastroenterology;9/7/2008, Vol. 14 Issue 33, p5154 

    Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic inflammatory process leads to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics