Decline in pneumococcal meningitis after the introduction of the heptavalent-pneumococcal conjugate vaccine in northern France

Dubos, F.; Marechal, I.; Husson, M. O.; Courouble, C.; Aurel, M.; Martinot, A.
November 2007
Archives of Disease in Childhood;Nov2007, Vol. 92 Issue 11, p1009
Academic Journal
Background: The impact of the heptavalent-pneumococcal conjugate vaccine on the incidence of pneumococcal meningitis in Europe has not yet been assessed. Objective: To determine whether heptavalent-pneumococcal conjugate vaccine implementation in northern France has resulted in a decrease in the incidence of pneumococcal meningitis in children. Design: Multicentre retrospective cohort study from 2000 through 2005. Settings: All paediatric departments of the 18 hospitals in northern France. Patients: Patients <18 years of age, admitted for laboratory-confirmed pneumococcal meningitis during the study period, were included. Interventions: Data were collected from medical files and the microbiological laboratories of each hospital and compared with the regional hospital discharge codes, using a capture-recapture method. Main outcome measures: The study assessed and compared global and age-related incidence rates of pneumococcal meningitis in 2001 (pre-vaccine era) and 2005. Results: 77 cases were found through the capture-recapture method. The incidence rate of pneumococcal meningitis varied from 1.65/100 000 children <18 years in 2001 to 0.80/100 000 children in 2005 (53% reduction, 95% CI 31 to 74; p = 0.08). This has so far been significant only for children <2 years of age (8.9/100 000 in 2001 to 1.8/100 000 in 2005; 82% reduction, 95% CI 52 to 95; p=0.03). Conclusion: A decline in pneumococcal meningitis has been observed in infants since heptavalent-pneumococcal conjugate vaccination began in our area.


Related Articles

  • Use of Pneumococcal Conjugate Vaccine to Decrease Rates of Bacterial Meningitis. Dagan, Ron // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, p1673 

    The article focuses on the therapeutic use of 7-valent pneumococcal conjugate vaccine (PCV7) to reduce the rates of bacterial meningitis. Study shows that the vaccine reduces pneumococcal infections in adult and pediatric contacts after its introduction. Its effect on the subset of pneumococcal...

  • Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd Immunity. Maiden, Martin C. J.; Lbarz-Pavón, Ana Belén; Urwin, Rachel; Gray, Stephen J.; Andrews, Nicholas J.; Clarke, Stuart C.; Walker, A. Mark; Evans, Meirion R.; Kroll, J. Simon; Neal, Keith R.; Ala'Aldeen, Dlawer A. A.; Crook, Derrick W.; Cann, Kathryn; Harrison, Sarah; Cunningham, Richard; Baxter, David; Kaczmarski, Edward; MacLennan, Jenny; Cameron, J. Claire; Stuart, James M. // Journal of Infectious Diseases;3/1/2008, Vol. 197 Issue 5, p737 

    Background. In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced in the United Kingdom for those under 19 years of age. The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by...

  • Epidemiologic and Microbiologic Characteristics of Recurrent Bacterial and Fungal Meningitis in The Netherlands, 1988-2005. van Driel, Joris J.; Bekker, Vincent; Spanjaard, Lodewijk; van der Ende, Arie; Kuijpers, Taco W. // Clinical Infectious Diseases;9/1/2008, Vol. 47 Issue 5, pe42 

    Background. Patients may experience multiple episodes of bacterial meningitis. Information from large studies of recurrent meningitis is limited. We evaluated the incidence of recurrent bacterial meningitis and the distribution of causative organisms in The Netherlands. Methods. Data for...

  • Changing Epidemiology of Pneumococcal Meningitis after the Introduction of Pneumococcal Conjugate Vaccine in the United States. Tsai, Chiaojung Jillian; Griffin, Marie R.; Nuorti, J. Pekka; Grijalva, Carlos G. // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, p1664 

    Background. Although hospitalizations due to invasive pneumococcal disease decreased after routine vaccination of young children with a 7-valent pneumococcal conjugate vaccine (PCV7) began in 2000, information on the trends in pneumococcal meningitis is limited. Methods. We estimated national...

  • Meningitis Vaccine Effective.  // Pediatrics for Parents;2009, Vol. 25 Issue 1, p15 

    The article presents a study which compares the rates of meningitis in 1998 and 2005 in the U.S. After the introduction of the pneumococcal meningitis vaccine in 2000, there was significant reduction of meningitis cases among children as well as adults. Meningitis rates in 1998 and 2005 dropped...

  • Poliomyelitis, Yemen -- update.  // Weekly Epidemiological Record;6/3/2005, Vol. 80 Issue 22, p194 

    The article reports on the cases of poliomyelitis in Yemen. The Ministry of Health of Yemen confirmed an additional 71 cases, bringing the total number of cases associated with this outbreak to 179. The outbreak was reported on April 22, 2005. Currently, 11 governorates are known to be affected...

  • Rethinking Recommendations for Use of Pneumococcal Vaccines in Adults. Whitney, Cynthia G.; Schaffner, William; Butler, Jay C. // Clinical Infectious Diseases;9/1/2001, Vol. 33 Issue 5, p1 

    Streptococcus pneumoniae remains a major cause of disease worldwide; the emergence of antibiotic-resistant strains emphasizes the importance of disease prevention by use of vaccines. Recent studies have provided information that is useful for the evaluation of current vaccine recommendations....

  • Daptomycin in experimental murine pneumococcal meningitis. Mook-Kanamori, Barry B.; Rouse, Mark S.; Cheol-In Kang; van de Beek, Diederik; Steckelberg, James M.; Patel, Robin // BMC Infectious Diseases;2009, Vol. 9 Issue 1, Special section p1 

    Background: Daptomycin, a lipopeptide antibiotic, could be an alternative to vancomycin for treatment of pneumococcal meningitis. We determined the activity of daptomycin versus vancomycin, with dexamethasone as an adjuvant, in a murine model of pneumococcal meningitis. Methods: Ninety-six 25-30...

  • Indirect Effect of Conjugate Vaccine on Adult Carriage of Streptococcus pneumoniae: An Explanation of Trends in Invasive Pneumococcal Disease. Hammitt, Laura L.; Bruden, Dana L.; Butler, Jay C.; Baggett, Henry C.; Hurlburt, Debby A.; Reasonover, Alisa; Hennessy, Thomas W. // Journal of Infectious Diseases;6/1/2006, Vol. 193 Issue 11, p1487 

    Background. Use of heptavalent protein-polysaccharide pneumococcal conjugate vaccine (PCV7) has been associated with decreases in PCV7-type invasive pneumococcal disease and nasopharyngeal (NP) carriage in children. Vaccine use has also indirectly decreased the rate of invasive disease in...


Read the Article

Other Topics