TITLE

Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study

AUTHOR(S)
Thomson, M. A.; Jenkins, H. R.; Bisset, W. M.; Heuschkel, R.; Kalra, D. S.; Green, M. R.; Wilson, D. C.; Geraint, M.
PUB. DATE
November 2007
SOURCE
Archives of Disease in Childhood;Nov2007, Vol. 92 Issue 11, p996
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. Design: Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. Setting: Six UK paediatric departments. Participants: 51 children (29 girls, 22 boys) aged 24 months to 11 years with chronic constipation (lasting ⩾3 months), defined as ⩽2 complete bowel movements per week and one of the following: pain on defaecation on 25% of days; ⩾25% of bowel movements with straining; ⩾25% of bowel movements with hard/lumpy stools. 47 children completed the double blind treatment. Main outcome measures: Number of complete defaecations per week (primary efficacy variable), total number of complete and incomplete defaecations per week, pain on defaecation, straining on defaecation, faecal incontinence, stool consistency, global assessment of treatment, adverse events and physical examination. Results: The mean number of complete defaecations per week was significantly higher for children on PEG+E than on placebo (3.12 (SD 2.05) v 1.45 (SD 1.20), respectively; p<0.001). Further significant differences in favour of PEG+E were observed for total number of defaecations per week (p = 0.003), pain on defaecation (p = 0.041 ), straining on defaecation (p<0.001), stool consistency (p<0.001) and percentage of hard stools (p=0.001). Treatment related adverse events (all mild or moderate) occurred in similar numbers of children on PEG+E (41%) and placebo during treatment (45%). Conclusions: PEG+E is significantly more effective than placebo, and appears to be safe and well tolerated in the treatment of chronic constipation in children.
ACCESSION #
27607717

 

Related Articles

  • The clinical effectiveness of Movicol in children with severe constipation: an outcome audit. Hanson, Sandra; Bansal, Nay // Paediatric Nursing;Mar2006, Vol. 18 Issue 2, p24 

    This audit reviewed the clinical effectiveness of polyethylene glycol 3350 plus electrolytes (PEG+E, Movicol®) in the management of severe paediatric constipation. A seven-day disimpaction regimen was initiated followed by a maintenance dose as appropriate. An information and support service...

  • Çocukluk çağı kabızlığında elektrolit içeren polietilen glikol kullanımı. Önal, Zerrin; Usta, Merve; Doğan, Yaşar; Kutlu, Tufan; Çokuğraş, Fügen Çullu; Erkan, Tülay // Turkish Pediatrics Archive / Turk Pediatri Arsivi;2008, Vol. 43 Issue 4, p135 

    Aim: To investigate the effectiveness and safety of polyethylene glycol (PEG 3350) as a therapy in children after the age of one year. Material and Method: The study included 50 cases, aged between 1-12 years. All of the cases were prescribed PEG 3350. We aimed one or two painless soft bowel...

  • Safety of Polyethylene Glycol for Children's Constipation. Miller, Karl E. // American Family Physician;2/1/2004, Vol. 69 Issue 3, p722 

    Discusses the study "Safety of Polyethylene glycol 3350 for the Treatment of Chronic Constipation in Children," by D.S. Pashankar et al., from the July 2003 issue of the journal "Archives of Pediatrics and Adolescent Medicine."

  • Treatment of severe childhood constipation with restorative proctocolectomy. Asipu, Deepti; Jaffray, Bruce // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2010, Vol. 95 Issue 11, p767 

    Objective To describe the clinical features of children with severe constipation and their outcome after restorative proctocolectomy. Design Observational study and health status questionnaire using gastrointestinal quality of life score (GIQL). Setting English regional paediatric surgery...

  • FOOD FOR THOUGHT. Crowthier, Penny // Positive Health;Nov2004, Issue 105, p28 

    Discusses the case of an eight-year-old girl presented with chronic constipation. Background of the patient's medical conditions; Diagnosis; Treatment.

  • Chronic Constipation in Your Child.  // American Family Physician;2/1/2006, Vol. 73 Issue 3, preceding p479 

    Presents information on chronic constipation in children. Description of constipation; Causes of constipation; Diagnosis of constipation.

  • Evaluation and Treatment of Constipation in Infants and Children. Biggs, Wendy S.; Dery, William H. // American Family Physician;2/1/2006, Vol. 73 Issue 3, p469 

    Constipation in children usually is functional and the result of stool retention. However, family physicians must be alert for red flags that may indicate the presence of an uncommon but serious organic cause of constipation, such as Hirschsprung's disease (congenital aganglionic megacolon),...

  • Assessment and Management of Pediatric Constipation in Primary Care. Coughlin, Elizabeth C. // Pediatric Nursing;Jul/Aug2003, Vol. 29 Issue 4, p296 

    Discusses the assessment and management of pediatric constipation which is a challenging problem frequently faced by primary care practitioners. Signs and symptoms of constipation; Organic and non-organic causes of constipation; Role of fiber in the management of constipation.

  • The solution to poor concentration in schoolchildren: just add water.  // Primary Health Care;Nov2004, Vol. 14 Issue 9, p7 

    Reports on the directive to the head teachers in Great Britain to allow school children to drink water in class to reduce the risk of constipation and help them stay alert. Instability of the teachers' responses to the problem of constipation to the children; Implication of the poor toilet in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics