TITLE

Pertussis requiring intensive care

AUTHOR(S)
Surridge, Julia; Segedin, Elizabeth R.; Grant, Cameron C.
PUB. DATE
November 2007
SOURCE
Archives of Disease in Childhood;Nov2007, Vol. 92 Issue 11, p970
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To describe children with pertussis who require intensive care. Design, setting and patients: An audit in Auckland, New Zealand, of pertussis admissions to the national paediatric intensive care unit (PICU) from 1991 to 2003. Results: 72 children, 97% of whom were <12 months old. The annual number of cases increased with time (p = 0.04). Forty patients (56%) were coughing for less than 8 days before admission. Apnoea or paroxysmal cough was present in 33 (83%) of these children. Thirty five (49%) received assisted ventilation. Four died. 19% were readmitted to PICU. Those readmitted presented with more atypical disease and had a shorter first admission but longer total PICU admission (9 vs 5 days, p=0.009). Of the 58 children from Auckland, nine either died (three) or had subsequent respiratory or neurodevelopmental problems (six). There was an increased risk (relative risk, 95% CI) of death or disability associated with having a co-morbidity (RR = 5.56, 1.50 to 8.15), an elevated lymphocyte count (RR=5.75, 1.54 to 13.65), presenting with seizures/encephalopathy (4.87, 1.18 to 8.34) or shock (6.50, 1.89 to 8.94), having a PIM score of 1% or more (RR = 6.20, 1.22 to 21.72), any abnormal neurological signs (RR = 9.65, 3.32 to 15.23) or being readmitted to PICU (RR=4.63, 1.44 to 8.82). Conclusions: Apnoea and paroxysmal cough are key symptoms of pertussis in those with shorter cough duration. Death or disability are frequent. Clinical factors define children at increased risk of these poor outcomes. Early discharge from PICU is associated with an increased risk of readmission and poor outcome.
ACCESSION #
27607711

 

Related Articles

  • Pertussis vaccination: Use of accellular pertussis vaccines among infants and young children.  // MMWR: Morbidity & Mortality Weekly Report;03/28/1997 Supplement RR-7, Vol. 46, p1 

    Focuses on whole cell pertussis vaccines and acellular pertussis vaccines for young infants and children in the United States (US). Information on studies pertaining to different types of pertussis vaccines; Rate of occurrence of this disease within the US; Discussion on studies of two...

  • Acellular pertussis vaccine provided limited protection.  // Infectious Diseases in Children;Oct2012, Vol. 25 Issue 10, p1 

    The article provides information on a study which found the inefficiency of acellular pertussis vaccine in children.

  • What is new in pertussis? Bamberger, Ellen S.; Srugo, Isaac // European Journal of Pediatrics;Feb2008, Vol. 167 Issue 2, p133 

    Despite high vaccination coverage, over the last fifteen years there has been a worldwide resurgence of B. pertussis infection. While classical pertussis in the prevaccine era was primarily a childhood disease, today with widespread vaccination, there has been a shift in the incidence of disease...

  • Pertussis vaccination decreased rate of severe infection, illness duration.  // Infectious Disease News;Apr2014, Vol. 27 Issue 4, p55 

    The article discusses a study and an accompanying commentary, published online on March 14, 2014 by "Clinical Infectious Diseases," regarding the lower rate of severe infection and illness duration in children immunized with acellular pertussis vaccine.

  • Changing epidemiology and emerging risk groups for pertussis. Galanis, Eleni; King, Arlene S.; Varughese, Paul; Halperin, Scott Alan // CMAJ: Canadian Medical Association Journal;2/14/2006, Vol. 174 Issue 4, p451 

    The article contends that the changing epidemiology of pertussis in Canada in 1990 has led to the emergence of groups at higher risk of the diseases. These groups include young infants, adolescents and adults. Pertussis is most easily diagnosed in young children because they present with...

  • Serum IgA Responses against Pertussis Proteins in Infected and Dutch wP or aP Vaccinated Children: An Additional Role in Pertussis Diagnostics. Hendrikx, Lotte H.; Öztürk, Kemal; de Rond, Lia G. H.; de Greeff, Sabine C.; Sanders, Elisabeth A. M.; Berbers, Guy A. M.; Buisman, Anne-Marie // PLoS ONE;2011, Vol. 6 Issue 11, p1 

    Background: Whooping cough is a respiratory disease caused by Bordetella pertussis, which induces mucosal IgA antibodies that appear to be relevant in protection. Serum IgA responses are measured after pertussis infection and might provide an additional role in pertussis diagnostics. However,...

  • Act now to curb pertussis epidemic. Dalton, Marguerite // New Zealand Doctor;9/22/2004, p28 

    Focuses on the prevalence of pertussis in New Zealand. Statistics of children with the disease; Increase in hospital admission rates for pertussis since 1970; Availability of vaccine for the disease.

  • Changing Pertussis Epidemiology: Everything Old is New Again. Clark, Thomas A. // Journal of Infectious Diseases;Apr2014, Vol. 209 Issue 7, p978 

    Before vaccination, pertussis was a universal disease of early childhood. Although apparent control of the disease in the United States and other countries was achieved through vaccination, pertussis is resurgent. Though acellular vaccines have been in use for 20 years, new data are emerging on...

  • Do not forget about protecting adolescents from pertussis. Bell, Edward A. // Infectious Diseases in Children;Oct2008, Vol. 21 Issue 10, p11 

    The article reports that although the incidence of pertussis, or whooping cough, in the U.S. has been dramatically reduced since the use of pertussis vaccine products in the 1950s, reported cases have been increasing since the 1980s. In 2005, 25,616 cases of pertussis were reported, 30% of which...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics