The Case Against Stress Ulcer Prophylaxis in 2007

Stevens, Alison M.; Thomas, Zachariah
November 2007
Hospital Pharmacy;Nov2007, Vol. 42 Issue 11, p995
Academic Journal
The article examines the impact of pharmacologic interventions on the treatment of the critically ill patient. It cites that splanchnic hypoperfusion is the primary insult that predisposes patients to stress-related mucosal damage (SRMD). Respiratory failure and high-dose corticosteroid use were associated with hemorrhage. Clostridium difficile associated disease (CDAD) was considered a potential hazard of antisecretory therapy.


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