Effects of rehabilitative exercise on peripheral muscle TNFα, IL-6, IGF-I and MyoD expression in patients with COPD

Vogiatzis, Ioannis; Stratakos, Grigoris; Simoes, Davina C. M.; Terzis, Gerasimos; Georgiadou, Olga; Roussos, Charis; Zakynthinos, Spyros
November 2007
Thorax;Nov2007, Vol. 62 Issue 11, p950
Academic Journal
Background: Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation. This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning. Methods: Fifteen patients with COPD (mean (SE) forced expiratory volume in 1 s 36 (4)% predicted) undertook high-intensity exercise training 3 days/week for 10 weeks. Before and after the training programme the concentration of tumour necrosis factor α (TNFα), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma was determined by ELISA, and vastus lateralis mRNA expression of TNFα, IL-6, total insulin- like growth factor-I (IGF-I) and its isoform mechanogrowth factor (MGF) and myogenic differentiation factor D (MyoD) were assessed by real-time PCR. Protein levels of TNFα, IGF-I and MyoD were measured by Western blotting. Results: Rehabilitation improved peak exercise work rate by 10 (2%) (p=0.004) and mean fibre cross- sectional area from 4061 (254) μm² to 4581 (241) μm² (p=0.001). Plasma inflammatory mediators and vastus lateralis expression of TNFα and IL-6 were not significantly modified by training. In contrast, there was a significant increase in mRNA expression of IGF-I (by 67 (22)%; p = 0.044), MGF (by 67 (15)%; p=0.002) and MyoD (by 116 (30)%; p=0.001 ). The increase observed at the mRNA level was also seen at the protein level for IGF-I (by 72 (36)%; p=0.046) and MyoD (by 67 (21)%; p=0.012). Conclusions: Pulmonary rehabilitation can induce peripheral muscle adaptations and modifications in factors regulating skeletal muscle hypertrophy and regeneration without decreasing the levels of systemic or local muscle inflammation.


Related Articles

  • Proinflammatory cytokines in Egyptian elderly with chronic obstructive pulmonary disease. Amer, Moatassem S.; Wahba, Hoda M. F.; Ashmawi, Samiha S. A.; Mabrouk, Randa Reda; Sharaf Eldeen, Ahmad A. E.; Hamza, Sarah A. // Lung India;Oct-Dec2010, Vol. 27 Issue 4, p225 

    Background: The pulmonary component of chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases....

  • TNF-α is associated with loss of lean body mass only in already cachectic COPD patients. Eagan, Tomas M. L.; Gabazza, Esteban C.; D'Alessandro-Gabazza, Corina; Gil-Bernabe, Paloma; Aoki, Shinya; Hardie, Jon A.; Bakke, Per S.; Wagner, Peter D. // Respiratory Research;Jun2012, Vol. 13 Issue 6, p1 

    Background: Systemic inflammation may contribute to cachexia in patients with chronic obstructive pulmonary disease (COPD). In this longitudinal study we assessed the association between circulating C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, and IL-6...

  • Smoking status and tumour necrosis factor-alpha mediated systemic inflammation in COPD patients. Tanni, Suzana E.; Pelegrino, Nilva R. G.; Angeleli, Aparecida Y. O.; Correa, Camila; Godoy, Irma // Journal of Inflammation;2010, Vol. 7, p29 

    Background: Smoking cause airway and systemic inflammation and COPD patients present low grade inflammation in peripheral blood. However, data on the influence of smoking itself on systemic inflammation in COPD patients are scarce. This study investigated the association between inflammation,...

  • Inflammation in Chronic HIV Infection: What Can We Do? Erlandson, Kristine M.; Campbell, Thomas B. // Journal of Infectious Diseases;8/1/2015, Vol. 212 Issue 3, p339 

    The authors comment on a study published in this issue of the journal which addressed the impact of initial antiretroviral regimen choices on subsequent changes in inflammation and immune activation markers among HIV-infected persons. C-reactive protein, interleukin 6 and tumor necrosis factor...

  • The association of low bone mineral density with systemic inflammation in clinically stable COPD. Liang, Binmiao; Feng, Yulin // Endocrine (1355008X);Aug2012, Vol. 42 Issue 1, p190 

    Chronic obstructive pulmonary disease (COPD) is known to be a systemic inflammatory disease which affects the function of many organs, and the low bone mineral density (BMD) may be the result of systemic inflammation. The aim of the present study was to explore the association of BMD with...

  • Enhanced inflammation with high carbohydrate intake during recovery from eccentric exercise. Depner, Chris M.; Kirwan, Rochelle D.; Frederickson, Sara J.; Miles, Mary P. // European Journal of Applied Physiology;Aug2010, Vol. 109 Issue 6, p1067 

    Inflammation associated with adipose tissue is modulated by macronutrient availability. For example, glucose increases inflammation in obese but not lean individuals. Little is known about how macronutrient intake influences inflammation associated with muscle. The aim of this study was to...

  • Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation. Durmazlar, Selda Pelin Kartal; Akgul, Ahmet; Eskioglu, Fatma // Mediators of Inflammation;2008, Vol. 2008, Special section p1 

    Objective. Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. Methods. Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy,...

  • Non-Insulin Resistant Obese Subjects Show More Postprandial Low Grade Systemic Inflammation than Control Lean Subjects. Caixas, Assumpta; Giménez-Palop, Olga; Broch, Montserrat; Vilardell, Carme; Megia, Ana; Simon, Imma; Giménez-Pérez, Gabriel; Mauricio, Didac; Vendrell, Joan; González-Clemente, Jose-Miguel; Gonzáez-Clemente, Jose-Miguel // Diabetes;Jun2007 Supplement 1, Vol. 56, pA468 

    Obesity and insulin resistance have been associated with low-grade systemic inflammation (LSGI). The aim of this study was to evaluate whether obese patients with normal insulin resistance showed an additional postprandial low-grade systemic inflammation in relation to lean subjects. Seven obese...

  • Tumor Necrosis Factor (TNF-α) and C-reactive Protein (CRP) are Positively Associated with the Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes. Eun-Sil Yeo; Ji-Yun Hwang; Ji Eun Park; Young Ju Choi; Kap Bum Huh; Wha Young Kim // Yonsei Medical Journal;7/1/2010, Vol. 51 Issue 4, p519 

    Purpose: Chronic low-grade inflammation may induce chronic kidney disease in patients with type 2 diabetes. This study investigated the relation between inflammatory biomarkers and chronic kidney disease in patients with type 2 diabetes, which has not yet been reported in Asian populations....


Read the Article


Sign out of this library

Other Topics