Risk of intracranial aneurysm bleeding in autosomal-dominant polycystic kidney disease

Ring, T.; Spiegelhalter, D.
December 2007
Kidney International;Dec2007, Vol. 72 Issue 11, p1400
Academic Journal
Patients with autosomal-dominant polycystic kidney disease (ADPKD) carry an increased risk of developing intracranial aneurysms. Bleeding from these sites is a significant complication with the events reported to cluster in some families. In this study we determined if individualized risk of aneurysm rupture can be estimated based on family history using a Bayesian random effects model. Previously reported data were used to define distributions and to construct a model that fit these data. Our results confirm that intracerebral aneurysm bleeding in ADPKD patients tends to cluster in families and that basic family history can provide a simple estimate of family-specific risk.Kidney International (2007) 72, 1400–1402; doi:10.1038/sj.ki.5002488; published online 19 September 2007


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