VEGF receptor inhibition slows the progression of polycystic kidney disease

Tao, Y.; Kim, J.; Yin, Y.; Zafar, I.; Falk, S.; He, Z.; Faubel, S.; Schrier, R. W.; Edelstein, C. L.
December 2007
Kidney International;Dec2007, Vol. 72 Issue 11, p1358
Academic Journal
Although the receptors for vascular endothelial growth factor (VEGF) exert their effects on vasculogenesis and angiogenesis through receptors located on endothelial cells, recent studies have shown that these receptors are also present on renal tubular epithelial cells. We investigated the role of VEGF on increased tubule cell proliferation in the Han:SPRD heterozygous (Cy/+) rat model of polycystic kidney disease. The levels of VEGF in the kidneys and the serum, and the expression of the two receptors on tubules were increased in Cy/+ rats. These rats were given ribozymes that specifically inhibited VEGFR1 and VEGFR2 mRNA expression. Tubule cell proliferation within the cysts was significantly decreased in the ribozyme-treated animals leading to decreased cystogenesis, blunted renal enlargement, and prevented the loss of renal function. Our studies show that inhibition of VEGF function may be an important therapeutic option to delay the progression of polycystic kidney disease.Kidney International (2007) 72, 1358–1366; doi:10.1038/sj.ki.5002550; published online 19 September 2007


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