Inhibition of thrombocyte aggregation during extracorporeal lung assist: a case report

Philipp, Alois; Müller, Thomas; Bein, Thomas; Foltan, Maik; Schmid, Franz-Xaver; Birnbaum, Dietrich; Schmid, Christof
July 2007
Perfusion;Jul2007, Vol. 22 Issue 4, p293
Academic Journal
Disclaimer: All authors declare that there are no beneficial arrangements with NovaLung® GmbH, Hechingen, Germany In extracorporeal lung assist, membrane oxygenators are used to improve gas exchange. Accumulations on the membranes of coagulation end products can increase resistance to blood flow and diffusion distance. Thus, functioning of the system can be impaired and, in extreme cases, lead to malfunction which may necessitate change out of the oxygenator. We describe a method that complements conventional continuous heparinisation with the administration of acetylsalicylic acid to inhibit thrombocyte aggregation.


Related Articles

  • aggregation, platelet. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p23 

    An encyclopedia entry for "platelet aggregation" is presented. It refers to the grouping of platelets that occurs when a blood vessel is damaged. It noted that platelet aggregation is the first step of blood clotting, helping close injured vessels. Drugs that help lessen platelet aggregation...

  • The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. Horner, Susanne; Menke, Kirsten; Hildebrandt, Caren; Kassack, Matthias; Nickel, Peter; Ullmann, Heiko; Mahaut-Smith, Martyn; Lambrecht, Günter // Naunyn-Schmiedeberg's Archives of Pharmacology;Jul2005, Vol. 372 Issue 1, p1 

    The role of ATP-stimulated P2X1 receptors in human platelets is still unclear. They may act alone or in synergy with other pathways, such as P2Y1 or P2Y12 receptors, to accelerate and enhance calcium mobilisation, shape change and aggregation. To date very few pharmacological means of...

  • Influence of aspirin or heparin on platelet function and postoperative blood loss after coronary artery bypass surgery. Sirvinskas, Edmundas; Veikutiene, Audrone; Grybauskas, Pranas; Cimbolaityte, Jurate; Mongirdiene, Ausra; Veikutis, Vincentas; Raliene, Laima // Perfusion;Jan2006, Vol. 21 Issue 1, p61 

    The aim of the study was to assess the effect of aspirin or heparin pretreatment on platelet function and bleeding in the early postoperative period after coronary artery bypass grafting (CABG) surgery. Seventy-five male patients with coronary artery disease who underwent CABG with...

  • Conjugated equine oestrogens and blood clotting: a follow-up report. Poller, L.; Thomson, Jean M.; Coope, Jean // British Medical Journal;4/9/1977, Vol. 1 Issue 6066, p935 

    Examines the study on blood clotting and platelet aggregation in women in Great Britain. Administration of long-term hormone replacement therapy with conjugated equine oestrogen; Efficacy of oestrogen in relieving menopausal symptoms; Increase in prothrombin and clotting times in hormone...

  • Comparative studies of blood coagulation and platelet aggregation in patients with cancer and nonmalignant diseases. Davis, Richard B.; Theologides, Athanasios; Kennedy, B. J.; Davis, R B; Theologides, A // Annals of Internal Medicine;Jul69, Vol. 71 Issue 1, p67 

    Presents comparative studies of blood coagulation and platelet aggregation in patients with cancer and nonmalignant diseases. Information on the diseases; Materials and methodology of the study; Results and discussion.

  • Clinical evaluation of six hollow-fibre membrane oxygenators. Visser, C.; de Jong, D. // Perfusion;1997, Vol. 12 Issue 6, p357 

    In a clinical evaluation to study the performance of hollow-fibre membrane oxygenators, we compared the gas exchange characteristics and the production of plasma free haemoglobin for different oxygenators. In this study, the data of the Univox, Cobe- Optima, Capiox-SX, Affinity, Safe II and...

  • Definition of Acetylsalicylic Acid Resistance Using Whole Blood Impedance Aggregometry in Patients Undergoing Coronary Artery Surgery. Petričević, Mate; Biočina, Bojan; Konosić, Sanja; Burcar, Ivan; Širić, Franjo; Mihaljević, Martina Zrno; Ivančan, Višnja; Svetina, Lucija; Gašparović, Hrvoje // Collegium Antropologicum;Sep2013, Vol. 37 Issue 3, p833 

    A beneficial effect of acetylsalicylic acid (ASA) on vein graft patency has been described, but some patients experience adverse cardiac events despite appropriate ASA treatment. Study aim was to define ASA resistance using Multiple electrode aggregometry (MEA) preoperatively in group of...

  • Effects of Aerobic Exercise and Training on Coagulation, Platelet Aggregation, and Plasma Lipids. San Jose, Maria Cristina Z.; Apaga, Natalie Emperatriz P.; Florento, Leila; Gan, Robert N. // Vascular Disease Prevention;Apr2005, Vol. 2 Issue 2, p145 

    Objective. Biological mechanisms mediating the effect of physical activity on the risk of coronary disease and stroke are not well established. We aimed to determine the effects of aerobic exercise and training on coagulation, platelet aggregation, and plasma lipids in healthy young adults....

  • The Biochemical and Physical Process of Fibrinolysis and Effects of Clot Structure and Stability on the Lysis Rate. Weisel, J. W.; Litvinov, R. I. // Cardiovascular & Hematological Agents in Medicinal Chemistry;2008, Vol. 6 Issue 3, p161 

    The effectiveness of fibrinolysis results from the combination of regulated enzymatic activity and the physical properties of the fibrin scaffold. Physiologically, clots or thrombi are dissolved from within via internal lysis. In contrast, with therapeutic thrombolysis, lytic agents are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics